Effects of nimodipine on noise-induced hearing loss

Flint A. Boettcher, Richard K. Caldwell, Michael Anne Gratton, David R. White, Lesa R. Miles

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The effects of nimodipine, a calcium channel blocker, on noise-induced hearing loss were examined in gerbils. Animals were implanted subcutaneously with a timed-release pellet containing either nimodipine (approximately 10 mg/kg/day) or placebo and exposed to either 102 or 107 dBA noise. Serum levels were tested in two subjects and were in the range known to protect humans from cerebral artery vasospasm and ischemia-related neurologic deficits. Nimodipine and control groups had similar amounts of noise-induced (a) permanent threshold shift; (b) reductions in distortion product otoacoustic emissions; (c) reductions in tuning and suppression of the compound action potential; and (d) loss of outer hair cells. The results suggest that nimodipine, at a dose which results in clinically relevant serum levels, does not provide protection from the effects of moderately intense noise exposures.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalHearing research
Volume121
Issue number1-2
DOIs
StatePublished - Jul 1 1998
Externally publishedYes

Keywords

  • Calcium channel blocker
  • Gerbil
  • Nimodipine
  • Noise-induced hearing loss

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