Effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures

Kenneth R. Henry; Michael D. McGinn; Dale R. Berard; Richard A. Chole

doi:10.1037/h0077787

Effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures

Kenneth R. Henry, Michael D. McGinn, Dale R. Berard, Richard A. Chole

Department of Otolaryngology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

T. N. Seyfried et al (1979) recently reported that the DBA/2J mouse genotype, which is innately susceptible to audiogenic seizures, has high neonatal levels of thyroxine (T₄) and that neonatal injections of T₄ induced susceptibility in the C57BL/6J mouse. In the experiment, neonatal T₄ injections (20 μg) produced a temporary peripheral auditory dysfunction that appeared to be conductive in nature in the C57BL/6J mouse (n = 106). A cochlear dysfunction was also seen in the DBA/2J mouse (n = 17) and in the acoustically primed C57BL/6J mouse. Since a peripheral auditory threshold elevation in these latter groups of mice appears to be causally related to their susceptibility to audiogenic seizures, it is likely that at least a portion of the susceptibility that Seyfried et al reported was due to the effects of T₄ on the ear. (34 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original language	English
Pages (from-to)	418-424
Number of pages	7
Journal	Journal of Comparative and Physiological Psychology
Volume	95
Issue number	3
DOIs	https://doi.org/10.1037/h0077787
State	Published - Jun 1981

Keywords

genotype &
neonatal thyroxine &
noise, auditory dysfunction &
susceptibility to audiogenic seizures, DBA/2J vs C57BL/6J mice

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10.1037/h0077787

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title = "Effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures",

abstract = "T. N. Seyfried et al (1979) recently reported that the DBA/2J mouse genotype, which is innately susceptible to audiogenic seizures, has high neonatal levels of thyroxine (T4) and that neonatal injections of T4 induced susceptibility in the C57BL/6J mouse. In the experiment, neonatal T4 injections (20 μg) produced a temporary peripheral auditory dysfunction that appeared to be conductive in nature in the C57BL/6J mouse (n = 106). A cochlear dysfunction was also seen in the DBA/2J mouse (n = 17) and in the acoustically primed C57BL/6J mouse. Since a peripheral auditory threshold elevation in these latter groups of mice appears to be causally related to their susceptibility to audiogenic seizures, it is likely that at least a portion of the susceptibility that Seyfried et al reported was due to the effects of T4 on the ear. (34 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).",

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author = "Henry, {Kenneth R.} and McGinn, {Michael D.} and Berard, {Dale R.} and Chole, {Richard A.}",

year = "1981",

month = jun,

doi = "10.1037/h0077787",

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journal = "Journal of Comparative and Physiological Psychology",

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T1 - Effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures

AU - Henry, Kenneth R.

AU - McGinn, Michael D.

AU - Berard, Dale R.

AU - Chole, Richard A.

PY - 1981/6

Y1 - 1981/6

N2 - T. N. Seyfried et al (1979) recently reported that the DBA/2J mouse genotype, which is innately susceptible to audiogenic seizures, has high neonatal levels of thyroxine (T4) and that neonatal injections of T4 induced susceptibility in the C57BL/6J mouse. In the experiment, neonatal T4 injections (20 μg) produced a temporary peripheral auditory dysfunction that appeared to be conductive in nature in the C57BL/6J mouse (n = 106). A cochlear dysfunction was also seen in the DBA/2J mouse (n = 17) and in the acoustically primed C57BL/6J mouse. Since a peripheral auditory threshold elevation in these latter groups of mice appears to be causally related to their susceptibility to audiogenic seizures, it is likely that at least a portion of the susceptibility that Seyfried et al reported was due to the effects of T4 on the ear. (34 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

AB - T. N. Seyfried et al (1979) recently reported that the DBA/2J mouse genotype, which is innately susceptible to audiogenic seizures, has high neonatal levels of thyroxine (T4) and that neonatal injections of T4 induced susceptibility in the C57BL/6J mouse. In the experiment, neonatal T4 injections (20 μg) produced a temporary peripheral auditory dysfunction that appeared to be conductive in nature in the C57BL/6J mouse (n = 106). A cochlear dysfunction was also seen in the DBA/2J mouse (n = 17) and in the acoustically primed C57BL/6J mouse. Since a peripheral auditory threshold elevation in these latter groups of mice appears to be causally related to their susceptibility to audiogenic seizures, it is likely that at least a portion of the susceptibility that Seyfried et al reported was due to the effects of T4 on the ear. (34 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

KW - genotype &

KW - neonatal thyroxine &

KW - noise, auditory dysfunction &

KW - susceptibility to audiogenic seizures, DBA/2J vs C57BL/6J mice

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VL - 95

SP - 418

EP - 424

JO - Journal of Comparative and Physiological Psychology

JF - Journal of Comparative and Physiological Psychology

IS - 3

ER -

Effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures

Abstract

Keywords

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