Effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures

Kenneth R. Henry, Michael D. McGinn, Dale R. Berard, Richard A. Chole

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


T. N. Seyfried et al (1979) recently reported that the DBA/2J mouse genotype, which is innately susceptible to audiogenic seizures, has high neonatal levels of thyroxine (T4) and that neonatal injections of T4 induced susceptibility in the C57BL/6J mouse. In the experiment, neonatal T4 injections (20 μg) produced a temporary peripheral auditory dysfunction that appeared to be conductive in nature in the C57BL/6J mouse (n = 106). A cochlear dysfunction was also seen in the DBA/2J mouse (n = 17) and in the acoustically primed C57BL/6J mouse. Since a peripheral auditory threshold elevation in these latter groups of mice appears to be causally related to their susceptibility to audiogenic seizures, it is likely that at least a portion of the susceptibility that Seyfried et al reported was due to the effects of T4 on the ear. (34 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalJournal of Comparative and Physiological Psychology
Issue number3
StatePublished - Jun 1981


  • genotype &
  • neonatal thyroxine &
  • noise, auditory dysfunction &
  • susceptibility to audiogenic seizures, DBA/2J vs C57BL/6J mice


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