TY - JOUR
T1 - Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
AU - Gehrig, Jeanette L.
AU - Venkatesh, Siddarth
AU - Chang, Hao Wei
AU - Hibberd, Matthew C.
AU - Kung, Vanderlene L.
AU - Cheng, Jiye
AU - Chen, Robert Y.
AU - Subramanian, Sathish
AU - Cowardin, Carrie A.
AU - Meier, Martin F.
AU - O’Donnell, David
AU - Talcott, Michael
AU - Spears, Larry D.
AU - Semenkovich, Clay F.
AU - Henrissat, Bernard
AU - Giannone, Richard J.
AU - Hettich, Robert L.
AU - Ilkayeva, Olga
AU - Muehlbauer, Michael
AU - Newgard, Christopher B.
AU - Sawyer, Christopher
AU - Head, Richard D.
AU - Rodionov, Dmitry A.
AU - Arzamasov, Aleksandr A.
AU - Leyn, Semen A.
AU - Osterman, Andrei L.
AU - Hossain, Md Iqbal
AU - Islam, Munirul
AU - Choudhury, Nuzhat
AU - Sarker, Shafiqul Alam
AU - Huq, Sayeeda
AU - Mahmud, Imteaz
AU - Mostafa, Ishita
AU - Mahfuz, Mustafa
AU - Barratt, Michael J.
AU - Ahmed, Tahmeed
AU - Gordon, Jeffrey I.
N1 - Publisher Copyright:
© 2019 American Association for the Advancement of Science. All rights reserved.
PY - 2019
Y1 - 2019
N2 - To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.
AB - To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.
UR - http://www.scopus.com/inward/record.url?scp=85069056249&partnerID=8YFLogxK
U2 - 10.1126/science.aau4732
DO - 10.1126/science.aau4732
M3 - Article
C2 - 31296738
AN - SCOPUS:85069056249
SN - 0036-8075
VL - 365
JO - Science
JF - Science
IS - 6449
M1 - Y
ER -