TY - JOUR
T1 - Effects of Mesenchymal Stem Cell-Derived Paracrine Signals and Their Delivery Strategies
AU - Chang, Calvin
AU - Yan, Jerry
AU - Yao, Zhicheng
AU - Zhang, Chi
AU - Li, Xiaowei
AU - Mao, Hai Quan
N1 - Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/4/7
Y1 - 2021/4/7
N2 - Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials-based therapeutic strategies for delivery of MSCs and MSC-derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.
AB - Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials-based therapeutic strategies for delivery of MSCs and MSC-derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.
KW - biomaterials
KW - extracellular vesicles
KW - mesenchymal stem cells
KW - microRNA
KW - paracrine signaling
KW - secretome
UR - http://www.scopus.com/inward/record.url?scp=85099174308&partnerID=8YFLogxK
U2 - 10.1002/adhm.202001689
DO - 10.1002/adhm.202001689
M3 - Review article
C2 - 33433956
AN - SCOPUS:85099174308
SN - 2192-2640
VL - 10
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 7
M1 - 2001689
ER -