TY - JOUR
T1 - Effects of leukotriene and cyclo-oxygenase inhibition on adaptive bone remodeling in the middle ear
AU - Sherman, Bret E.
AU - Chole, Richard A.
N1 - Funding Information:
From the Department of Otolaryngology–Head and Neck Surgery, School of Medicine, University of California, Davis (Dr Sherman); and the Department of Otolaryngology–Head and Neck Surgery, School of Medicine, Washington University (Dr Chole). Supported by a grant from the NIH (R01-DC00263-11). Presented at the Annual Meeting of the American Academy of Otolaryngology–Head and Neck Surgery, New Orleans, LA, September 26-29, 1999. Reprint requests: Richard A. Chole, MD, PhD, Department of Oto-laryngology, Washington University School of Medicine, Campus Box 8115, 517 S Euclid Ave, St Louis, MO 63110-1007. Copyright © 2000 by the American Academy of Otolaryngology– Head and Neck Surgery Foundation, Inc. 0194-5998/2000/$12.00 + 0 23/10/105996 doi:10.1067/mhn.2000.105996
PY - 2000/7
Y1 - 2000/7
N2 - Abnormal bone remodeling is associated with important otolaryngologic diseases. In such diseases, the mechanisms of osteoclastic control underlie the pathologic processes. It is known that strain applied to auditory bullae induces bone resorption - an effect mediated by prostaglandins and blocked by cyclo-oxygenase inhibitors. It is also known that cyclo-oxygenase inhibition shunts arachidonic acid into alternate metabolic pathways, mainly the lipoxygenase pathway with leukotriene production. The role of these metabolites in adaptive bone remodeling is unknown. Using the gerbilline bulla as a model, we infused BW755c (dual lipoxygenase/cyclo-oxygenase inhibitor) and L-663,536 (5-lipoxygenase inhibitor) into animals undergoing middle ear pressurization. After 7 days, the bulla bones were harvested, and osteoclasts were quantified histomorphometrically. The results showed that neither treatment altered pressure induced resorption. However, BW755c significantly increased resorption in unpressurized bone when compared with control values. Because BW775c blocks both lipoxygenase and cyclo- oxygenase pathways, the results suggest an alternate pathway in middle ear bone resorption.
AB - Abnormal bone remodeling is associated with important otolaryngologic diseases. In such diseases, the mechanisms of osteoclastic control underlie the pathologic processes. It is known that strain applied to auditory bullae induces bone resorption - an effect mediated by prostaglandins and blocked by cyclo-oxygenase inhibitors. It is also known that cyclo-oxygenase inhibition shunts arachidonic acid into alternate metabolic pathways, mainly the lipoxygenase pathway with leukotriene production. The role of these metabolites in adaptive bone remodeling is unknown. Using the gerbilline bulla as a model, we infused BW755c (dual lipoxygenase/cyclo-oxygenase inhibitor) and L-663,536 (5-lipoxygenase inhibitor) into animals undergoing middle ear pressurization. After 7 days, the bulla bones were harvested, and osteoclasts were quantified histomorphometrically. The results showed that neither treatment altered pressure induced resorption. However, BW755c significantly increased resorption in unpressurized bone when compared with control values. Because BW775c blocks both lipoxygenase and cyclo- oxygenase pathways, the results suggest an alternate pathway in middle ear bone resorption.
UR - http://www.scopus.com/inward/record.url?scp=0033910332&partnerID=8YFLogxK
U2 - 10.1067/mhn.2000.105996
DO - 10.1067/mhn.2000.105996
M3 - Review article
C2 - 10889472
AN - SCOPUS:0033910332
SN - 0194-5998
VL - 123
SP - 1
EP - 8
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 1 I
ER -