Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles

Masakazu Takayasu; Ralph G. Dacey

doi:10.1016/0006-8993(89)91207-9

Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles

Masakazu Takayasu, Ralph G. Dacey

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The vasoactive properties of inhibitory (γ-aminobutyric acid (GABA), glycine) and excitatory (glutamate, aspartate) amino acid neurotransmitters were studied in isolated rat cerebral parenchymal arterioles. None of these neurotransmitters had a significant effect on vessel diameter at concentrations between 10^-9 and 10^-3 M, except for 10^-3 M glycine. These amino acid neurotransmitters are unlikely to play a role in regulation or pathophysiology of the cerebral microcirculation by directly changing vascular diameter.

Original language	English
Pages (from-to)	393-396
Number of pages	4
Journal	Brain Research
Volume	482
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(89)91207-9
State	Published - Mar 20 1989

Keywords

Amino acid
Aspartate
Cerebral microcirculation
Glutamate
Glycine
Neurotransmitter
Vascular smooth muscle
γ-Aminobutyric acid

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10.1016/0006-8993(89)91207-9

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title = "Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles",

abstract = "The vasoactive properties of inhibitory (γ-aminobutyric acid (GABA), glycine) and excitatory (glutamate, aspartate) amino acid neurotransmitters were studied in isolated rat cerebral parenchymal arterioles. None of these neurotransmitters had a significant effect on vessel diameter at concentrations between 10-9 and 10-3 M, except for 10-3 M glycine. These amino acid neurotransmitters are unlikely to play a role in regulation or pathophysiology of the cerebral microcirculation by directly changing vascular diameter.",

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AU - Takayasu, Masakazu

AU - Dacey, Ralph G.

PY - 1989/3/20

Y1 - 1989/3/20

N2 - The vasoactive properties of inhibitory (γ-aminobutyric acid (GABA), glycine) and excitatory (glutamate, aspartate) amino acid neurotransmitters were studied in isolated rat cerebral parenchymal arterioles. None of these neurotransmitters had a significant effect on vessel diameter at concentrations between 10-9 and 10-3 M, except for 10-3 M glycine. These amino acid neurotransmitters are unlikely to play a role in regulation or pathophysiology of the cerebral microcirculation by directly changing vascular diameter.

AB - The vasoactive properties of inhibitory (γ-aminobutyric acid (GABA), glycine) and excitatory (glutamate, aspartate) amino acid neurotransmitters were studied in isolated rat cerebral parenchymal arterioles. None of these neurotransmitters had a significant effect on vessel diameter at concentrations between 10-9 and 10-3 M, except for 10-3 M glycine. These amino acid neurotransmitters are unlikely to play a role in regulation or pathophysiology of the cerebral microcirculation by directly changing vascular diameter.

KW - Amino acid

KW - Aspartate

KW - Cerebral microcirculation

KW - Glutamate

KW - Glycine

KW - Neurotransmitter

KW - Vascular smooth muscle

KW - γ-Aminobutyric acid

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SN - 0006-8993

VL - 482

SP - 393

EP - 396

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles

Abstract

Keywords

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