Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles

Masakazu Takayasu, Ralph G. Dacey

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The vasoactive properties of inhibitory (γ-aminobutyric acid (GABA), glycine) and excitatory (glutamate, aspartate) amino acid neurotransmitters were studied in isolated rat cerebral parenchymal arterioles. None of these neurotransmitters had a significant effect on vessel diameter at concentrations between 10-9 and 10-3 M, except for 10-3 M glycine. These amino acid neurotransmitters are unlikely to play a role in regulation or pathophysiology of the cerebral microcirculation by directly changing vascular diameter.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
JournalBrain Research
Volume482
Issue number2
DOIs
StatePublished - Mar 20 1989

Keywords

  • Amino acid
  • Aspartate
  • Cerebral microcirculation
  • Glutamate
  • Glycine
  • Neurotransmitter
  • Vascular smooth muscle
  • γ-Aminobutyric acid

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