Effects of hydrocortisone acetate on pulmonary alveolar macrophage colony-forming cells

H. S. Lin, C. Kuhn, D. M. Chen

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We investigated the effect of prolonged monocytopenia induced by daily injections of hydrocortisone acetate on the number of alveolar cells and alveolar macrophage colony-forming cells (AL-CFC) in mice. We did not observe an appreciable reduction in the number of either alveolar macrophages or AL-CFC under this experimental condition, which markedly inhibited the blood monocyte concentration over 10 days. These results suggest the existence of a mechanism by which the number of alveolar macrophages, including AL-CFC, can be maintained without a continuous migration of blood monocytes into alveolar spaces.

Original languageEnglish
Pages (from-to)712-715
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume125
Issue number6
StatePublished - Jan 1 1982

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