TY - JOUR
T1 - Effects of hormone replacement therapy on cognitive performance in elderly women
AU - Binder, Ellen F.
AU - Schechtman, Kenneth B.
AU - Birge, Stanley J.
AU - Williams, Daniel B.
AU - Kohrt, Wendy M.
N1 - Funding Information:
This work was supported by NIH Claude Pepper Older Americans Independence Center Award grant P01-AG13629, and by NIH General Clinical Research Center grant 5-M01-RR00036. Product support was provided by Wyeth-Ayerst Laboratories. The authors wish to acknowledge the excellent technical assistance of Debbie Bronder, Linda Ball, Joseph Wilmot, Edward Weiss, and Timothy Meyer.
PY - 2001/4/20
Y1 - 2001/4/20
N2 - Objective: To determine the effects of 9 months of hormone replacement therapy (HRT) on cognitive performance in women aged 75 years and older. Methods: A 9-month randomized, double-blinded, placebo-controlled parallel trial. Fifty-two elderly postmenopausal women (age range 75-91 years) without known contraindications to HRT or evidence of dementia or depression were enrolled. Participants were randomly assigned in a 1:2 ratio to placebo or conjugated estrogens at 0.625 mg/d plus trimonthly medroxyprogesterone acetate at 5 mg/d for 13 days (HRT). Main outcome measures were change from baseline and rate of change from baseline for the following psychometric tests: Verbal Fluency Test, Weschler Paired Associate Learning and 20 min Delayed Recall, Trailmaking A and B Tests, Cancellation Random Letter and Random Form Tests. Results: At baseline, women in the HRT group reported a younger age of onset of menopause and a higher prevalence of hysterectomy, but otherwise did not differ from women in the placebo group. After 9 months of treatment, there were no significant group differences for any of the cognitive performance measures. The lack of an observed group-by-time difference for all cognitive tests remained after controlling for age of onset of menopause, education, and previous hysterectomy. Conclusions: Although conclusions are limited by small sample size and the relatively short duration of treatment, results suggest that 9 months of estrogen replacement in combination with trimonthly progestin does not improve cognitive performance in women over 75 years who do not have dementia or depression.
AB - Objective: To determine the effects of 9 months of hormone replacement therapy (HRT) on cognitive performance in women aged 75 years and older. Methods: A 9-month randomized, double-blinded, placebo-controlled parallel trial. Fifty-two elderly postmenopausal women (age range 75-91 years) without known contraindications to HRT or evidence of dementia or depression were enrolled. Participants were randomly assigned in a 1:2 ratio to placebo or conjugated estrogens at 0.625 mg/d plus trimonthly medroxyprogesterone acetate at 5 mg/d for 13 days (HRT). Main outcome measures were change from baseline and rate of change from baseline for the following psychometric tests: Verbal Fluency Test, Weschler Paired Associate Learning and 20 min Delayed Recall, Trailmaking A and B Tests, Cancellation Random Letter and Random Form Tests. Results: At baseline, women in the HRT group reported a younger age of onset of menopause and a higher prevalence of hysterectomy, but otherwise did not differ from women in the placebo group. After 9 months of treatment, there were no significant group differences for any of the cognitive performance measures. The lack of an observed group-by-time difference for all cognitive tests remained after controlling for age of onset of menopause, education, and previous hysterectomy. Conclusions: Although conclusions are limited by small sample size and the relatively short duration of treatment, results suggest that 9 months of estrogen replacement in combination with trimonthly progestin does not improve cognitive performance in women over 75 years who do not have dementia or depression.
KW - Cognitive performance
KW - Endometrical hyperplasia
KW - Epidemiological research
KW - Estrogen
KW - Hormone replacement therapy (HRT)
KW - Psychometric tests
UR - http://www.scopus.com/inward/record.url?scp=0035917913&partnerID=8YFLogxK
U2 - 10.1016/S0378-5122(00)00214-0
DO - 10.1016/S0378-5122(00)00214-0
M3 - Article
C2 - 11306202
AN - SCOPUS:0035917913
SN - 0378-5122
VL - 38
SP - 137
EP - 146
JO - Maturitas
JF - Maturitas
IS - 2
ER -