Effects of FKBP-12 ligands following tibial nerve injury in rats

D. B. Becker, J. N. Jensen, T. M. Myckatyn, V. B. Doolabh, D. A. Hunter, S. E. Mackinnon

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The neuroregenerative properties of FK506, an FKBP-12 ligand that inhibits calcineurin, and V-10,367, an FKBP-12 ligand that does not inhibit calcineurin, were evaluated in crush and transection models. Rats were randomly assigned to one of seven groups, including untreated controls and FK506- or V-10,367-treated experimental groups. Following crush or transection nerve injury, animals were assessed with walking tracks, and histomorphometry. FK506-treated animals demonstrated significant functional recovery 11 days following crush and 18 days following transection injury. In untreated and V-10,367 treated animals, nerves recovered 13 days following crush injury, but did not improve significantly prior to sacrifice at 28 days in animals sustaining a transection iniury. No statistically significant differences in histomorphometric parameters were identified between any of the groups. The study confirms that FK506 accelerates recovery from tibial nerve injury.

Original languageEnglish
Pages (from-to)613-620
Number of pages8
JournalJournal of reconstructive microsurgery
Volume16
Issue number8
StatePublished - 2000

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