Effects of Exercise on Glucose Tolerance and Insulin Resistance: Brief Review and Some Preliminary Results

JOHN O. HOLLOSZY, JOAN SCHULTZ, JUDITH KUSNIERKIEWICZ, JAMES M. HAGBERG, ALI A. EHSANI

Research output: Contribution to journalArticle

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Abstract

ABSTRACT. With aging, glucose tolerance (GT) declines, plasma insulin concentration increases, and sensitivity to the action of insulin declines. Evidence is accumulating that this decline in glucose tolerance and insulin sensitivity can be prevented by regularly performed vigorous exercise. Preliminary results are presented in this paper showing that prolonged, strenuous and frequent exercise can also completely normalize GT by decreasing resistance to insulin in some patients with mild non insulin dependent diabetes mellitus (NIDDM) and in some individuals with impaired glucose tolerance (IGT). Exercise appears to be effective in normalizing GT only in patients who still have an adequate capacity to secrete insulin, and in whom insulin resistance is the major cause for abnormal GT. The amount of exercise required to normalize GT in such patients appears to be in the range of 25 to 35 km per week of running, or a comparable amount of another form of exercise, performed on a regular basis. 1986 Association for the Publication of the Journal of Internal Medicine

Original languageEnglish
Pages (from-to)55-65
Number of pages11
JournalActa Medica Scandinavica
Volume220
Issue number711 S
DOIs
StatePublished - Jan 1 1986

Keywords

  • aging
  • exercise
  • glucose tolerance
  • impaired glucose tolerance
  • insulin resistance
  • non insulin dependent diabetes mellitus

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