TY - JOUR
T1 - Effects of Exercise on Glucose Tolerance and Insulin Resistance
T2 - Brief Review and Some Preliminary Results
AU - HOLLOSZY, JOHN O.
AU - SCHULTZ, JOAN
AU - KUSNIERKIEWICZ, JUDITH
AU - HAGBERG, JAMES M.
AU - EHSANI, ALI A.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - ABSTRACT. With aging, glucose tolerance (GT) declines, plasma insulin concentration increases, and sensitivity to the action of insulin declines. Evidence is accumulating that this decline in glucose tolerance and insulin sensitivity can be prevented by regularly performed vigorous exercise. Preliminary results are presented in this paper showing that prolonged, strenuous and frequent exercise can also completely normalize GT by decreasing resistance to insulin in some patients with mild non insulin dependent diabetes mellitus (NIDDM) and in some individuals with impaired glucose tolerance (IGT). Exercise appears to be effective in normalizing GT only in patients who still have an adequate capacity to secrete insulin, and in whom insulin resistance is the major cause for abnormal GT. The amount of exercise required to normalize GT in such patients appears to be in the range of 25 to 35 km per week of running, or a comparable amount of another form of exercise, performed on a regular basis. 1986 Association for the Publication of the Journal of Internal Medicine
AB - ABSTRACT. With aging, glucose tolerance (GT) declines, plasma insulin concentration increases, and sensitivity to the action of insulin declines. Evidence is accumulating that this decline in glucose tolerance and insulin sensitivity can be prevented by regularly performed vigorous exercise. Preliminary results are presented in this paper showing that prolonged, strenuous and frequent exercise can also completely normalize GT by decreasing resistance to insulin in some patients with mild non insulin dependent diabetes mellitus (NIDDM) and in some individuals with impaired glucose tolerance (IGT). Exercise appears to be effective in normalizing GT only in patients who still have an adequate capacity to secrete insulin, and in whom insulin resistance is the major cause for abnormal GT. The amount of exercise required to normalize GT in such patients appears to be in the range of 25 to 35 km per week of running, or a comparable amount of another form of exercise, performed on a regular basis. 1986 Association for the Publication of the Journal of Internal Medicine
KW - aging
KW - exercise
KW - glucose tolerance
KW - impaired glucose tolerance
KW - insulin resistance
KW - non insulin dependent diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0022523667&partnerID=8YFLogxK
U2 - 10.1111/j.0954-6820.1986.tb08932.x
DO - 10.1111/j.0954-6820.1986.tb08932.x
M3 - Article
C2 - 3535414
AN - SCOPUS:0022523667
VL - 220
SP - 55
EP - 65
JO - Acta Medica Scandinavica
JF - Acta Medica Scandinavica
SN - 0001-6101
IS - 711 S
ER -