@article{99b07288aee04ca38a35fa5242783bb3,
title = "Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma",
abstract = " Background: Although pre-puberty asthma is more prevalent in males, after puberty through middle-age, asthma is more prevalent in females. The surge of sex hormones with puberty might explain this gender switch. Methods: To examine the effects of sex hormones on lung function and symptoms with puberty, Tanner stage was assessed in 187 children 6-18 years of age (59% severe) enrolled in the NIH/NHLBI Severe Asthma Research Program (SARP). The effects of circulating sex hormones (n = 68; testosterone, dehydroepiandrosterone sulfate (DHEA-S), estrogen, and progesterone) on lung function and 4 week symptom control (ACQ6) in cross-section were tested by linear regression. Results: From pre-/early to late puberty, lung function did not change significantly but ACQ6 scores improved in males with severe asthma. By contrast females had lower post-BD FEV 1 % and FVC% and worse ACQ6 scores with late puberty assessed by breast development. In males log DHEA-S levels, which increased by Tanner stage, associated positively with pre- and post-BD FEV 1 %, pre-BD FVC %, and negatively (improved) with ACQ6. Patients treated with high-dose inhaled corticosteroids had similar levels of circulating DHEA-S. In females, estradiol levels increased by Tanner stage, and associated negatively with pre-BD FEV 1 % and FVC %. Conclusions: These results support beneficial effects of androgens on lung function and symptom control and weak deleterious effects of estradiol on lung function in children with asthma. Longitudinal data are necessary to confirm these cross-sectional findings and to further elucidate hormonal mechanisms informing sex differences in asthma features with puberty.",
keywords = "Asthma, Estradiol, Lung function, Puberty, Sex hormones, Testosterone",
author = "DeBoer, {Mark D.} and Phillips, {Brenda R.} and Mauger, {David T.} and Joe Zein and Erzurum, {Serpil C.} and Fitzpatrick, {Anne M.} and Gaston, {Benjamin M.} and Ross Myers and Ross, {Kristie R.} and James Chmiel and Lee, {Min Jie} and Fahy, {John V.} and Michael Peters and Ly, {Ngoc P.} and Wenzel, {Sally E.} and Fajt, {Merritt L.} and Fernando Holguin and Moore, {Wendy C.} and Peters, {Stephen P.} and Deborah Meyers and Bleecker, {Eugene R.} and Mario Castro and Coverstone, {Andrea M.} and Bacharier, {Leonard B.} and Jarjour, {Nizar N.} and Sorkness, {Ronald L.} and Sima Ramratnam and Irani, {Anne Marie} and Elliot Israel and Bruce Levy and Wanda Phipatanakul and Gaffin, {Jonathan M.} and {Gerald Teague}, W.",
note = "Funding Information: The authors wish to acknowledge the children and their parents who participated in the SARP III study, as well as the hard work of the site-based study coordinators and regulatory personnel, the oversight of the members of the Data Safety and Monitoring Board, and the diligent efforts of the NIH/ NHLBI project officers and staff who administered the protocol. SARP Principal/Co-Principal Investigators. Eugene R. Bleecker, PI, Wake Forest University, U10 HL109164. Mario Castro, PI, Washington University, U10 HL109257. John V. Fahy, PI, University of California San Francisco, U10 HL109146. Elliot Israel and Bruce Levy, Co-PIs, Brigham and Women's Hospital, U10 HL109172. Benjamin Gaston, PI, Rainbow Babies and Children's Hospital Virginia-Cleveland Consortium, U10 HL109250. Serpil Erzurum, Co-PI, Cleveland Clinic, Virginia-Cleveland Consortium, U10 HL109250. W. Gerald Teague, Co-PI, Univ. of Virginia, Virginia-Cleveland Consortium, U10 HL109250. Nizar N. Jarjour, PI, University of Wisconsin, U10 HL109168. Sally E. Wenzel, PI, University of Pittsburgh, U10 HL109152. David T. Mauger, PI, DCC, Penn State University, U10 HL109086-04. Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = apr,
day = "10",
doi = "10.1186/s12890-018-0612-x",
language = "English",
volume = "18",
journal = "BMC Pulmonary Medicine",
issn = "1471-2466",
number = "1",
}