Effects of endogenous serum neuregulin-1β on morbidity and mortality in patients with heart failure and left ventricular systolic dysfunction

Jennifer Miao; Shi Huang; Yan Ru Su; Carrie A. Lenneman; Meera Wright; Frank E. Harrell; Douglas B. Sawyer; Daniel J. Lenihan

doi:10.1080/1354750X.2018.1485054

Effects of endogenous serum neuregulin-1β on morbidity and mortality in patients with heart failure and left ventricular systolic dysfunction

Jennifer Miao, Shi Huang, Yan Ru Su, Carrie A. Lenneman, Meera Wright, Frank E. Harrell, Douglas B. Sawyer, Daniel J. Lenihan

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Context: Improved left ventricular ejection fraction (LVEF) following administration of recombinant human Neuregulin-1β (NRG), epidermal growth factor (EGF) involved in cardiomyocyte repair/survival, has been observed in patients with systolic heart failure (HF). Methods: Serum NRG was measured by ELISA in 248 patients with NYHA class I–IV HF. Results: NRG exhibited a marginally significant effect on LVEF trajectory over 11 months (p = 0.07). There is no apparent level of NRG that predicts improved survival. Conclusions: There is a potential relationship between serum NRG and improved LVEF, indicating the need to investigate the utility of NRG in predicting HF outcomes, including LVEF maintenance.

Original language	English
Pages (from-to)	704-708
Number of pages	5
Journal	Biomarkers
Volume	23
Issue number	7
DOIs	https://doi.org/10.1080/1354750X.2018.1485054
State	Published - Oct 3 2018

Keywords

Neuregulin-1
cardiomyopathy
heart failure
left ventricular ejection fraction
left ventricular systolic dysfunction

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title = "Effects of endogenous serum neuregulin-1β on morbidity and mortality in patients with heart failure and left ventricular systolic dysfunction",

abstract = "Context: Improved left ventricular ejection fraction (LVEF) following administration of recombinant human Neuregulin-1β (NRG), epidermal growth factor (EGF) involved in cardiomyocyte repair/survival, has been observed in patients with systolic heart failure (HF). Methods: Serum NRG was measured by ELISA in 248 patients with NYHA class I–IV HF. Results: NRG exhibited a marginally significant effect on LVEF trajectory over 11 months (p = 0.07). There is no apparent level of NRG that predicts improved survival. Conclusions: There is a potential relationship between serum NRG and improved LVEF, indicating the need to investigate the utility of NRG in predicting HF outcomes, including LVEF maintenance.",

keywords = "Neuregulin-1, cardiomyopathy, heart failure, left ventricular ejection fraction, left ventricular systolic dysfunction",

author = "Jennifer Miao and Shi Huang and Su, {Yan Ru} and Lenneman, {Carrie A.} and Meera Wright and Harrell, {Frank E.} and Sawyer, {Douglas B.} and Lenihan, {Daniel J.}",

year = "2018",

month = oct,

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doi = "10.1080/1354750X.2018.1485054",

language = "English",

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journal = "Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals",

issn = "1354-750X",

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Effects of endogenous serum neuregulin-1β on morbidity and mortality in patients with heart failure and left ventricular systolic dysfunction. / Miao, Jennifer; Huang, Shi; Su, Yan Ru; Lenneman, Carrie A.; Wright, Meera; Harrell, Frank E.; Sawyer, Douglas B.; Lenihan, Daniel J.

In: Biomarkers, Vol. 23, No. 7, 03.10.2018, p. 704-708.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of endogenous serum neuregulin-1β on morbidity and mortality in patients with heart failure and left ventricular systolic dysfunction

AU - Miao, Jennifer

AU - Huang, Shi

AU - Su, Yan Ru

AU - Lenneman, Carrie A.

AU - Wright, Meera

AU - Harrell, Frank E.

AU - Sawyer, Douglas B.

AU - Lenihan, Daniel J.

PY - 2018/10/3

Y1 - 2018/10/3

N2 - Context: Improved left ventricular ejection fraction (LVEF) following administration of recombinant human Neuregulin-1β (NRG), epidermal growth factor (EGF) involved in cardiomyocyte repair/survival, has been observed in patients with systolic heart failure (HF). Methods: Serum NRG was measured by ELISA in 248 patients with NYHA class I–IV HF. Results: NRG exhibited a marginally significant effect on LVEF trajectory over 11 months (p = 0.07). There is no apparent level of NRG that predicts improved survival. Conclusions: There is a potential relationship between serum NRG and improved LVEF, indicating the need to investigate the utility of NRG in predicting HF outcomes, including LVEF maintenance.

AB - Context: Improved left ventricular ejection fraction (LVEF) following administration of recombinant human Neuregulin-1β (NRG), epidermal growth factor (EGF) involved in cardiomyocyte repair/survival, has been observed in patients with systolic heart failure (HF). Methods: Serum NRG was measured by ELISA in 248 patients with NYHA class I–IV HF. Results: NRG exhibited a marginally significant effect on LVEF trajectory over 11 months (p = 0.07). There is no apparent level of NRG that predicts improved survival. Conclusions: There is a potential relationship between serum NRG and improved LVEF, indicating the need to investigate the utility of NRG in predicting HF outcomes, including LVEF maintenance.

KW - Neuregulin-1

KW - cardiomyopathy

KW - heart failure

KW - left ventricular ejection fraction

KW - left ventricular systolic dysfunction

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