Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children

Susan V. Lynch, Robert A. Wood, Homer Boushey, Leonard B. Bacharier, Gordon R. Bloomberg, Meyer Kattan, George T. O'Connor, Megan T. Sandel, Agustin Calatroni, Elizabeth Matsui, Christine C. Johnson, Henry Lynn, Cynthia M. Visness, Katy F. Jaffee, Peter J. Gergen, Diane R. Gold, Rosalind J. Wright, Kei Fujimura, Marcus Rauch, William W. BusseJames E. Gern

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213 Scopus citations

Abstract

Background Wheezing illnesses cause major morbidity in infants and are frequent precursors to asthma. Objective We sought to examine environmental factors associated with recurrent wheezing in inner-city environments. Methods The Urban Environment and Childhood Asthma study examined a birth cohort at high risk for asthma (n = 560) in Baltimore, Boston, New York, and St Louis. Environmental assessments included allergen exposure and, in a nested case-control study of 104 children, the bacterial content of house dust collected in the first year of life. Associations were determined among environmental factors, aeroallergen sensitization, and recurrent wheezing at age 3 years. Results Cumulative allergen exposure over the first 3 years was associated with allergic sensitization, and sensitization at age 3 years was related to recurrent wheeze. In contrast, first-year exposure to cockroach, mouse, and cat allergens was negatively associated with recurrent wheeze (odds ratio, 0.60, 0.65, and 0.75, respectively; P ≤.01). Differences in house dust bacterial content in the first year, especially reduced exposure to specific Firmicutes and Bacteriodetes, was associated with atopy and atopic wheeze. Exposure to high levels of both allergens and this subset of bacteria in the first year of life was most common among children without atopy or wheeze. Conclusions In inner-city environments children with the highest exposure to specific allergens and bacteria during their first year were least likely to have recurrent wheeze and allergic sensitization. These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early life might be beneficial and suggest new preventive strategies for wheezing and allergic diseases.

Original languageEnglish
Pages (from-to)593-601.e12
JournalJournal of Allergy and Clinical Immunology
Volume134
Issue number3
DOIs
StatePublished - Sep 2014

Keywords

  • Asthma
  • allergen exposure
  • atopy
  • inner city
  • microbial exposure

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    Lynch, S. V., Wood, R. A., Boushey, H., Bacharier, L. B., Bloomberg, G. R., Kattan, M., O'Connor, G. T., Sandel, M. T., Calatroni, A., Matsui, E., Johnson, C. C., Lynn, H., Visness, C. M., Jaffee, K. F., Gergen, P. J., Gold, D. R., Wright, R. J., Fujimura, K., Rauch, M., ... Gern, J. E. (2014). Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. Journal of Allergy and Clinical Immunology, 134(3), 593-601.e12. https://doi.org/10.1016/j.jaci.2014.04.018