TY - JOUR
T1 - Effects of digoxin and enalapril on heart period variability and response to head-up tilt in normal subjects
AU - Kaufman, Elizabeth S.
AU - Bosner, Matthew S.
AU - Bigger, J. Thomas
AU - Stein, Phyllis K.
AU - Kleiger, Robert E.
AU - Rolnitzky, Linda M.
AU - Steinman, Richard C.
AU - Fleiss, Joseph L.
N1 - Funding Information:
From the Division of Cardiology, Department of Medicine, and Division of Biostatistics, School of Public Health, Columbia University, New York, New York, and the Division of Cardiology, Department of Medicine, The Jewish Hospital of St. Louis, Washington University School of Medicine, St. Louis, Missouri. This study was supported in part by Grants HI-41552 and HL-70204 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; by Grant RR-00645 from the Research Resources Administration; and by funds from the Dover Foundation, the Bugher Foundation, and Adelaide Segerman, New York, New York. Manuscript received September 21, 1992; revised manuscript received January 26, 1993, and accepted January 29.
PY - 1993/7/1
Y1 - 1993/7/1
N2 - To test the effects of digitalis and angiotensinconverting enzyme inhibition on the RR interval variability in an electrocardiogram, 20 normal subjects were given digoxin 0.25 mg, enalapril 10 mg, and placebo twice daily in a randomized, doubleblind, crossover study. Continuous 24-hour electrocardiographic recordings obtained on day 5 of each treatment were analyzed and several time domain and power spectral measures of heart period variability were calculated. Digoxin markedly increased (up to 51%) indexes of vagal modulation of heart period without changing mean RR interval. Enalapril did not change any measure of heart period variability despite a modest hypertensive effect. To determine the effect of each treatment on the response to orthostatic stress, 10 subjects also underwent 15 minutes of 60 ° headup tilt; power spectra were calculated for 15 minutes at 0 ° and at 60 ° of tilt. Neither active treatment affected the response to head-up tilt.
AB - To test the effects of digitalis and angiotensinconverting enzyme inhibition on the RR interval variability in an electrocardiogram, 20 normal subjects were given digoxin 0.25 mg, enalapril 10 mg, and placebo twice daily in a randomized, doubleblind, crossover study. Continuous 24-hour electrocardiographic recordings obtained on day 5 of each treatment were analyzed and several time domain and power spectral measures of heart period variability were calculated. Digoxin markedly increased (up to 51%) indexes of vagal modulation of heart period without changing mean RR interval. Enalapril did not change any measure of heart period variability despite a modest hypertensive effect. To determine the effect of each treatment on the response to orthostatic stress, 10 subjects also underwent 15 minutes of 60 ° headup tilt; power spectra were calculated for 15 minutes at 0 ° and at 60 ° of tilt. Neither active treatment affected the response to head-up tilt.
UR - http://www.scopus.com/inward/record.url?scp=0027267027&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(93)90226-3
DO - 10.1016/0002-9149(93)90226-3
M3 - Article
C2 - 8517437
AN - SCOPUS:0027267027
SN - 0002-9149
VL - 72
SP - 95
EP - 99
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 1
ER -