Effects of Dietary Medium-Chain Triglyceride Supplementation on the Serum Metabolome of Young Adult and Senior Canines

Yuanlong Pan, Miriam Sindelar, Ethan Stancliffe, Leah P. Shriver, Rondo P. Middleton, Gary J. Patti

Research output: Contribution to journalArticlepeer-review

Abstract

Canine cognitive dysfunction syndrome is a progressive condition that is characterized by deficits in memory and learning, behavioral changes, and decreased response to stimuli. This disorder, which currently lacks effective therapies, leads to a reduced quality of life for both dogs and their owners. Diets rich in medium-chain triglycerides (MCTs) have been shown to positively impact brain health; however, their effects on systemic metabolism have been incompletely characterized. This study used an untargeted metabolomics platform to profile alterations in the serum metabolome of young adult and senior canines fed a diet containing MCTs. MCT feeding induced alterations in the levels of circulating complex lipids (including triacylglycerides, glycerophospholipids, and cholesterol esters), ketone bodies, glutamine, and some branched-chain and aromatic amino acids. Collectively, the results suggest that MCT supplementation rewires global metabolism and could potentially improve health beyond cognitive function.

Original languageEnglish
Article number3577
JournalAnimals
Volume14
Issue number24
DOIs
StatePublished - Dec 2024

Keywords

  • amino acids
  • dog
  • ketone bodies
  • lipids
  • medium-chain triglycerides (MCTs)
  • metabolism
  • metabolomics

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