Abstract
Canine cognitive dysfunction syndrome is a progressive condition that is characterized by deficits in memory and learning, behavioral changes, and decreased response to stimuli. This disorder, which currently lacks effective therapies, leads to a reduced quality of life for both dogs and their owners. Diets rich in medium-chain triglycerides (MCTs) have been shown to positively impact brain health; however, their effects on systemic metabolism have been incompletely characterized. This study used an untargeted metabolomics platform to profile alterations in the serum metabolome of young adult and senior canines fed a diet containing MCTs. MCT feeding induced alterations in the levels of circulating complex lipids (including triacylglycerides, glycerophospholipids, and cholesterol esters), ketone bodies, glutamine, and some branched-chain and aromatic amino acids. Collectively, the results suggest that MCT supplementation rewires global metabolism and could potentially improve health beyond cognitive function.
Original language | English |
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Article number | 3577 |
Journal | Animals |
Volume | 14 |
Issue number | 24 |
DOIs | |
State | Published - Dec 2024 |
Keywords
- amino acids
- dog
- ketone bodies
- lipids
- medium-chain triglycerides (MCTs)
- metabolism
- metabolomics