Effects of chronic experimental streptozotocin-induced diabetes on the noradrenergic and peptidergic innervation of the rat alimentary tract

Robert E. Schmidt; David A. Plurad; Kevin A. Roth

doi:10.1016/0006-8993(88)90478-7

Effects of chronic experimental streptozotocin-induced diabetes on the noradrenergic and peptidergic innervation of the rat alimentary tract

Robert E. Schmidt
, David A. Plurad
, Kevin A. Roth

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Immunohistologic localization of tyrosine hydroxylase (TOH), dopamine-β-hydroxylase (DBH) and selected neuropeptides (vasoactive intestinal polypeptide, gastrin-releasing peptide (GRP)/bombesin, substance P, Leu-enkephalin, Met-enkephalin, dynorphin B, neuropeptide Y (NPY), somatostatin) was used to investigate the innervation of the small bowel in a rat model of diabetic autonomic neuropathy. Paravascular mesenteric nerves (extrinsic) and intramural nerves of chronically (12-18 month) diabetic rats were characterized by the presence of numerous, markedly swollen dystrophic axons which stained intensely for TOH and DBH. The peptidergic complement of axons, however, showed no evidence of comparable dystrophic axonopathy.

Original language	English
Pages (from-to)	353-360
Number of pages	8
Journal	Brain Research
Volume	458
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)90478-7
State	Published - Aug 23 1988

Keywords

Diabetes
Neuroaxonal dystrophy
Neuropathy
Neuropeptide
Sympathetic

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10.1016/0006-8993(88)90478-7

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title = "Effects of chronic experimental streptozotocin-induced diabetes on the noradrenergic and peptidergic innervation of the rat alimentary tract",

abstract = "Immunohistologic localization of tyrosine hydroxylase (TOH), dopamine-β-hydroxylase (DBH) and selected neuropeptides (vasoactive intestinal polypeptide, gastrin-releasing peptide (GRP)/bombesin, substance P, Leu-enkephalin, Met-enkephalin, dynorphin B, neuropeptide Y (NPY), somatostatin) was used to investigate the innervation of the small bowel in a rat model of diabetic autonomic neuropathy. Paravascular mesenteric nerves (extrinsic) and intramural nerves of chronically (12-18 month) diabetic rats were characterized by the presence of numerous, markedly swollen dystrophic axons which stained intensely for TOH and DBH. The peptidergic complement of axons, however, showed no evidence of comparable dystrophic axonopathy.",

keywords = "Diabetes, Neuroaxonal dystrophy, Neuropathy, Neuropeptide, Sympathetic",

author = "Schmidt, \{Robert E.\} and Plurad, \{David A.\} and Roth, \{Kevin A.\}",

note = "Funding Information: We would like to thank Barb Cogswell and Sandy Brickey for their photographica nd secretariaal ssis-tance, respectivelyT.h is work was supportedb y NIH Grant DK19645, Research Career Development Award DK01516 (R.E.S.) and a grant from the Neu-rex Corporation( K.A.R.). Streptozotociwn as a gift from the Upjohn Company. We also thank Dr. Jack D. Barchas (StanfordU niversity)f or gifts of peptide antisera.",

year = "1988",

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doi = "10.1016/0006-8993(88)90478-7",

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T1 - Effects of chronic experimental streptozotocin-induced diabetes on the noradrenergic and peptidergic innervation of the rat alimentary tract

AU - Schmidt, Robert E.

AU - Plurad, David A.

AU - Roth, Kevin A.

N1 - Funding Information: We would like to thank Barb Cogswell and Sandy Brickey for their photographica nd secretariaal ssis-tance, respectivelyT.h is work was supportedb y NIH Grant DK19645, Research Career Development Award DK01516 (R.E.S.) and a grant from the Neu-rex Corporation( K.A.R.). Streptozotociwn as a gift from the Upjohn Company. We also thank Dr. Jack D. Barchas (StanfordU niversity)f or gifts of peptide antisera.

PY - 1988/8/23

Y1 - 1988/8/23

N2 - Immunohistologic localization of tyrosine hydroxylase (TOH), dopamine-β-hydroxylase (DBH) and selected neuropeptides (vasoactive intestinal polypeptide, gastrin-releasing peptide (GRP)/bombesin, substance P, Leu-enkephalin, Met-enkephalin, dynorphin B, neuropeptide Y (NPY), somatostatin) was used to investigate the innervation of the small bowel in a rat model of diabetic autonomic neuropathy. Paravascular mesenteric nerves (extrinsic) and intramural nerves of chronically (12-18 month) diabetic rats were characterized by the presence of numerous, markedly swollen dystrophic axons which stained intensely for TOH and DBH. The peptidergic complement of axons, however, showed no evidence of comparable dystrophic axonopathy.

AB - Immunohistologic localization of tyrosine hydroxylase (TOH), dopamine-β-hydroxylase (DBH) and selected neuropeptides (vasoactive intestinal polypeptide, gastrin-releasing peptide (GRP)/bombesin, substance P, Leu-enkephalin, Met-enkephalin, dynorphin B, neuropeptide Y (NPY), somatostatin) was used to investigate the innervation of the small bowel in a rat model of diabetic autonomic neuropathy. Paravascular mesenteric nerves (extrinsic) and intramural nerves of chronically (12-18 month) diabetic rats were characterized by the presence of numerous, markedly swollen dystrophic axons which stained intensely for TOH and DBH. The peptidergic complement of axons, however, showed no evidence of comparable dystrophic axonopathy.

KW - Diabetes

KW - Neuroaxonal dystrophy

KW - Neuropathy

KW - Neuropeptide

KW - Sympathetic

UR - https://www.scopus.com/pages/publications/0023695985

U2 - 10.1016/0006-8993(88)90478-7

DO - 10.1016/0006-8993(88)90478-7

M3 - Article

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AN - SCOPUS:0023695985

SN - 0006-8993

VL - 458

SP - 353

EP - 360

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Effects of chronic experimental streptozotocin-induced diabetes on the noradrenergic and peptidergic innervation of the rat alimentary tract

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Keywords

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