Effects of cellular electromechanical coupling on functional heterogeneity in a one-dimensional tissue model of the myocardium

Anastasia Khokhlova; Nathalie Balakina-Vikulova; Leonid Katsnelson; Olga Solovyova

doi:10.1016/j.compbiomed.2017.03.021

Effects of cellular electromechanical coupling on functional heterogeneity in a one-dimensional tissue model of the myocardium

Anastasia Khokhlova, Nathalie Balakina-Vikulova, Leonid Katsnelson, Olga Solovyova

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation patterns produced by our 1D model are consistent with the transmural regional strain patterns obtained experimentally in the normal heart in vivo. The modelling results suggest that the mechanical load may essentially affect the transmural gradients in the electrical and mechanical properties of interacting myocytes within a tissue, thereby regulating global myocardial output.

Original language	English
Pages (from-to)	147-155
Number of pages	9
Journal	Computers in Biology and Medicine
Volume	84
DOIs	https://doi.org/10.1016/j.compbiomed.2017.03.021
State	Published - May 1 2017

Keywords

Cardiac heterogeneity
Cardiac mechanics
Electromechanical coupling

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10.1016/j.compbiomed.2017.03.021

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title = "Effects of cellular electromechanical coupling on functional heterogeneity in a one-dimensional tissue model of the myocardium",

abstract = "Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation patterns produced by our 1D model are consistent with the transmural regional strain patterns obtained experimentally in the normal heart in vivo. The modelling results suggest that the mechanical load may essentially affect the transmural gradients in the electrical and mechanical properties of interacting myocytes within a tissue, thereby regulating global myocardial output.",

keywords = "Cardiac heterogeneity, Cardiac mechanics, Electromechanical coupling",

author = "Anastasia Khokhlova and Nathalie Balakina-Vikulova and Leonid Katsnelson and Olga Solovyova",

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T1 - Effects of cellular electromechanical coupling on functional heterogeneity in a one-dimensional tissue model of the myocardium

AU - Khokhlova, Anastasia

AU - Balakina-Vikulova, Nathalie

AU - Katsnelson, Leonid

AU - Solovyova, Olga

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation patterns produced by our 1D model are consistent with the transmural regional strain patterns obtained experimentally in the normal heart in vivo. The modelling results suggest that the mechanical load may essentially affect the transmural gradients in the electrical and mechanical properties of interacting myocytes within a tissue, thereby regulating global myocardial output.

AB - Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation patterns produced by our 1D model are consistent with the transmural regional strain patterns obtained experimentally in the normal heart in vivo. The modelling results suggest that the mechanical load may essentially affect the transmural gradients in the electrical and mechanical properties of interacting myocytes within a tissue, thereby regulating global myocardial output.

KW - Cardiac heterogeneity

KW - Cardiac mechanics

KW - Electromechanical coupling

UR - https://www.scopus.com/pages/publications/85016441515

U2 - 10.1016/j.compbiomed.2017.03.021

DO - 10.1016/j.compbiomed.2017.03.021

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AN - SCOPUS:85016441515

SN - 0010-4825

VL - 84

SP - 147

EP - 155

JO - Computers in Biology and Medicine

JF - Computers in Biology and Medicine

ER -

Effects of cellular electromechanical coupling on functional heterogeneity in a one-dimensional tissue model of the myocardium

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Keywords

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