Effects of Autohydrolyzed Lignin and Lactulose on Gallbladder Bile Composition in Hamsters

Ori D. Rotstein; Ruth M. Kay; Morris Wayman; Kin Po Siu; Steven M. Strasberg

doi:10.1021/jf00105a008

Effects of Autohydrolyzed Lignin and Lactulose on Gallbladder Bile Composition in Hamsters

Ori D. Rotstein, Ruth M. Kay, Morris Wayman, Kin Po Siu, Steven M. Strasberg

Department of Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Autohydrolyzed lignin was found to bind bile acids in vitro, an effect which was enhanced at low pH. Lignin with and without lactulose was fed to Golden Syrian hamsters to determine whether it could improve gallbladder bile composition by inducing small increases in bile acid excretion/ synthesis. Lignin-supplemented diets increased daily fecal lithocholate excretion in association with a significant reduction in biliary cholesterol saturation. Lignin and lactulose did not affect daily neutral steroid excretion, but the combination decreased cholesterol degradation in the intestine. Further experiments are required to assess the efficacy of autohydrolyzed lignin and lactulose in the prevention of cholesterol gallstone disease.

Original language	English
Pages (from-to)	472-475
Number of pages	4
Journal	Journal of Agricultural and Food Chemistry
Volume	29
Issue number	3
DOIs	https://doi.org/10.1021/jf00105a008
State	Published - May 1981

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title = "Effects of Autohydrolyzed Lignin and Lactulose on Gallbladder Bile Composition in Hamsters",

abstract = "Autohydrolyzed lignin was found to bind bile acids in vitro, an effect which was enhanced at low pH. Lignin with and without lactulose was fed to Golden Syrian hamsters to determine whether it could improve gallbladder bile composition by inducing small increases in bile acid excretion/ synthesis. Lignin-supplemented diets increased daily fecal lithocholate excretion in association with a significant reduction in biliary cholesterol saturation. Lignin and lactulose did not affect daily neutral steroid excretion, but the combination decreased cholesterol degradation in the intestine. Further experiments are required to assess the efficacy of autohydrolyzed lignin and lactulose in the prevention of cholesterol gallstone disease.",

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year = "1981",

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AU - Rotstein, Ori D.

AU - Kay, Ruth M.

AU - Wayman, Morris

AU - Siu, Kin Po

AU - Strasberg, Steven M.

PY - 1981/5

Y1 - 1981/5

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AB - Autohydrolyzed lignin was found to bind bile acids in vitro, an effect which was enhanced at low pH. Lignin with and without lactulose was fed to Golden Syrian hamsters to determine whether it could improve gallbladder bile composition by inducing small increases in bile acid excretion/ synthesis. Lignin-supplemented diets increased daily fecal lithocholate excretion in association with a significant reduction in biliary cholesterol saturation. Lignin and lactulose did not affect daily neutral steroid excretion, but the combination decreased cholesterol degradation in the intestine. Further experiments are required to assess the efficacy of autohydrolyzed lignin and lactulose in the prevention of cholesterol gallstone disease.

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SP - 472

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JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

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ER -

Effects of Autohydrolyzed Lignin and Lactulose on Gallbladder Bile Composition in Hamsters

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