TY - GEN
T1 - Effects of antiresorptive agents on osteomyelitis
T2 - Novel insights into the pathogenesis of osteonecrosis of the jaw
AU - Li, Dan
AU - Gromov, Kirill
AU - Proulx, Steven T.
AU - Xie, Chao
AU - Li, Jie
AU - Crane, Daniel P.
AU - Søballe, Kjeld
AU - O'Keefe, Regis J.
AU - Awad, Hani A.
AU - Xing, Lianping
AU - Schwarz, Edward M.
PY - 2010/3
Y1 - 2010/3
N2 - The effects of antiresorptive agents (e.g., alendronate [Aln], osteoprotegerin [OPG]) on bone infection are unknown. Thus, their effects on implant-associated osteomyelitis (OM) were investigated in mice using PBS (placebo), gentamycin, and etanercept (TNFR:Fc) controls. None of the drugs affected humoral immunity, angiogenesis, or chronic infection. However, the significant (P < 0.05 vs. PBS) inhibition of cortical osteolysis and decreased draining lymph node size in Aln- and OPG-treated mice was associated with a significant (P < 0.05) increase in the incidence of high-grade infections during the establishment of OM. In contrast, the high-grade infections in TNFR:Fc-treated mice were associated with immunosuppression, as evidenced by the absence of granulomas and presence of Gram+ biofilm in the bone marrow. Collectively, these findings indicate that although antiresorptive agents do not exacerbate chronic OM, they can increase the bacterial load during early infection by decreasing lymphatic drainage and preventing the removal of necrotic bone that harbors the bacteria.
AB - The effects of antiresorptive agents (e.g., alendronate [Aln], osteoprotegerin [OPG]) on bone infection are unknown. Thus, their effects on implant-associated osteomyelitis (OM) were investigated in mice using PBS (placebo), gentamycin, and etanercept (TNFR:Fc) controls. None of the drugs affected humoral immunity, angiogenesis, or chronic infection. However, the significant (P < 0.05 vs. PBS) inhibition of cortical osteolysis and decreased draining lymph node size in Aln- and OPG-treated mice was associated with a significant (P < 0.05) increase in the incidence of high-grade infections during the establishment of OM. In contrast, the high-grade infections in TNFR:Fc-treated mice were associated with immunosuppression, as evidenced by the absence of granulomas and presence of Gram+ biofilm in the bone marrow. Collectively, these findings indicate that although antiresorptive agents do not exacerbate chronic OM, they can increase the bacterial load during early infection by decreasing lymphatic drainage and preventing the removal of necrotic bone that harbors the bacteria.
KW - Antiresorptive therapy
KW - Osteomyelitis
KW - TNFR:Fc
UR - http://www.scopus.com/inward/record.url?scp=77950658125&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05210.x
DO - 10.1111/j.1749-6632.2009.05210.x
M3 - Conference contribution
C2 - 20392222
AN - SCOPUS:77950658125
SN - 9781573317856
T3 - Annals of the New York Academy of Sciences
SP - 84
EP - 94
BT - Skeletal Biology and Medicine
PB - Blackwell Publishing Inc.
ER -