Effects of a biologically active LHRH fragment on CA1 hippocampal neurons

Yushe Chen, Michael Wong, Robert L. Moss

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The actions of a behaviorally active luteinizing hormone-releasing hormone fragment, Ac-LHRH(5-10), on CA1 pyramidal cells were studied utilizing conventional intracellular recordings from the in vitro rat hippocampal slice preparation. The behaviorally active fragment (10-7 M) and the natural decapeptide [LHRH(1-10), 10-8 M] had similar actions on CA1 neurons: a long-duration depolarization associated with increased input resistance, a reduction in the slow afterhyperpolarization (AHP), and a decrease in accommodation. In contrast, a biologically inactive LHRH fragment [LHRH(1-6) at 10-7 M] had no effect on electrical properties of CA1 neurons. These data suggest that Ac-LHRH(5-10), like LHRH(1-10), may have a modulatory action on hippocampal neurons.

Original languageEnglish
Pages (from-to)1079-1081
Number of pages3
JournalPeptides
Volume14
Issue number5
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • Accommodation
  • Afterhyperpolarization
  • Behaviorally active LHRH fragment
  • Depolarization
  • Hippocampal slice
  • LHRH

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