13 Scopus citations


The actions of a behaviorally active luteinizing hormone-releasing hormone fragment, Ac-LHRH(5-10), on CA1 pyramidal cells were studied utilizing conventional intracellular recordings from the in vitro rat hippocampal slice preparation. The behaviorally active fragment (10-7 M) and the natural decapeptide [LHRH(1-10), 10-8 M] had similar actions on CA1 neurons: a long-duration depolarization associated with increased input resistance, a reduction in the slow afterhyperpolarization (AHP), and a decrease in accommodation. In contrast, a biologically inactive LHRH fragment [LHRH(1-6) at 10-7 M] had no effect on electrical properties of CA1 neurons. These data suggest that Ac-LHRH(5-10), like LHRH(1-10), may have a modulatory action on hippocampal neurons.

Original languageEnglish
Pages (from-to)1079-1081
Number of pages3
Issue number5
StatePublished - 1993


  • Accommodation
  • Afterhyperpolarization
  • Behaviorally active LHRH fragment
  • Depolarization
  • Hippocampal slice
  • LHRH


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