Effector T cell plasticity: Flexibility in the face of changing circumstances

Kenneth M. Murphy; Brigitta Stockinger

doi:10.1038/ni.1899

Effector T cell plasticity: Flexibility in the face of changing circumstances

Kenneth M. Murphy, Brigitta Stockinger

Research output: Contribution to journal › Review article › peer-review

386 Scopus citations

Abstract

As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.

Original language	English
Pages (from-to)	674-680
Number of pages	7
Journal	Nature immunology
Volume	11
Issue number	8
DOIs	https://doi.org/10.1038/ni.1899
State	Published - Aug 2010

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abstract = "As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.",

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Effector T cell plasticity: Flexibility in the face of changing circumstances

Abstract

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