Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

IVY Network Collaborators

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3 Scopus citations

Abstract

Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P >. 05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.

Original languageEnglish
Pages (from-to)1694-1700
Number of pages7
JournalJournal of Infectious Diseases
Volume225
Issue number10
DOIs
StatePublished - May 15 2022

Keywords

  • COVID-19
  • chronic medical conditions
  • preexisting conditions
  • vaccine effectiveness

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