Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022

IVY Network

doi:10.15585/MMWR.MM7112E1

Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022

IVY Network

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	459-465
Number of pages	7
Journal	Morbidity and Mortality Weekly Report
Volume	71
Issue number	12
DOIs	https://doi.org/10.15585/MMWR.MM7112E1
State	Published - Mar 25 2022

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10.15585/MMWR.MM7112E1

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@article{7c4b2c5af9cc455b9fd3ce22fd4ccf18,

title = "Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022",

author = "{IVY Network} and Tenforde, {Mark W.} and Self, {Wesley H.} and Manjusha Gaglani and Ginde, {Adit A.} and Douin, {David J.} and Talbot, {H. Keipp} and Casey, {Jonathan D.} and Mohr, {Nicholas M.} and Anne Zepeski and Tresa McNeal and Shekhar Ghamande and Gibbs, {Kevin W.} and Files, {D. Clark} and Hager, {David N.} and Arber Shehu and Prekker, {Matthew E.} and Frosch, {Anne E.} and Gong, {Michelle N.} and Amira Mohamed and Johnson, {Nicholas J.} and Vasisht Srinivasan and Steingrub, {Jay S.} and Peltan, {Ithan D.} and Brown, {Samuel M.} and Martin, {Emily T.} and Monto, {Arnold S.} and Akram Khan and Hough, {Catherine L.} and Busse, {Laurence W.} and Abhijit Duggal and Wilson, {Jennifer G.} and Nida Qadir and Chang, {Steven Y.} and Christopher Mallow and Carolina Rivas and Babcock, {Hilary M.} and Kwon, {Jennie H.} and Exline, {Matthew C.} and Mena Botros and Lauring, {Adam S.} and Shapiro, {Nathan I.} and Natasha Halasa and Chappell, {James D.} and Grijalva, {Carlos G.} and Rice, {Todd W.} and Jones, {Ian D.} and Stubblefield, {William B.} and Adrienne Baughman and Womack, {Kelsey N.} and Rhoads, {Jillian P.} and Lindsell, {Christopher J.} and Hart, {Kimberly W.} and Yuwei Zhu and Katherine Adams and Diya Surie and McMorrow, {Meredith L.} and Patel, {Manish M.} and Nicole Calhoun and Judy Herrick and Eric Hoffman and Amanda McKillop and Kempapura Murthy and Michael Smith and Martha Zayed and {De Souza}, Lesley and Ryan Kindle and Kozikowski, {Lori Ann} and Scott Ouellette and Sherell Thornton-Thompson and Michael Bolstad and Robert Ciottone and Brianna Coviello and Arnaldo Devilla and Ana Grafals and Conor Higgins and Carlo Ottanelli and Kimberly Redman and Douglas Scaffidi and Alexander Weingart and Nathaniel Lewis and Samantha Olson and Kiran Ashok and Connery Brennan and Omar Mehkri and Megan Mitchell and Bryan Poynter and Nicholas Stanley and {ten Lohuis}, Caitlin and Sean Caspers and Heidi Erikson and Audrey Hendrickson and Olivia Kaus and Ellen Maruggi and Tyler Scharber and Walker Tordsen and Valerie Aston and Robert Bowers and Jeffrey Jorgensen and Jennifer King and Harith Ali and Rothman, {Richard E.} and Rahul Nair and Chen, {Jen Ting} and Sarah Karow and Emily Robart and Maldonado, {Paulo Nunes} and Maryiam Khan and Preston So and Elizabeth Schwartz and Madison So and Michael Weigand and Andrea Luong and Jesus Martinez and Bao Huynh and Habiba Ibrahim and Cynthia Villanueva-Vargas and Haeun Jung and Juliana Villanueva-Vargas and Suha Quadri and Jun Gordon and Joe Levitt and Cynthia Perez and Anita Visweswaran and Jonasel Roque and Adreanne Rivera and Trevor Frankel and Jennifer Goff and David Huynh and Kelly Jensen and Conner Driver and Ian Chambers and Paul Nassar and Lori Stout and Zita Sibenaller and Alicia Walter and Jasmine Mares and Logan Olson and Bradley Clinansmith and Hayley Gershengorn and Carolina Rivas and McSpadden, {E. J.} and Rachel Truscon and Anne Kaniclides and Lara Thomas and Ramsay Bielak and Valvano, {Weronika Damek} and Rebecca Fong and Fitzsimmons, {William J.} and Christopher Blair and Andrew Valesano and Leigh Baker and Julie Gilbert and Crider, {Christine D.} and Steinbock, {Kyle A.} and Paulson, {Thomas C.} and Anderson, {Layla A.} and Christy Kampe and Jakea Johnson and Short, {Laura L.} and Ezzell, {Lauren J.} and Whitsett, {Margaret E.} and McHenry, {Rendie E.} and Hargrave, {Samarian J.} and Marica Blair and Luther, {Jennifer L.} and Pulido, {Claudia Guevara} and Peterson, {Bryan P.M.} and Mary LaRose and Leigha Landreth and Madeline Hicks and Lisa Parks and Jahnavi Bongu and David McDonald and Candice Cass and Sondra Seiler and David Park and Tiffany Hink and Meghan Wallace and Burnham, {Carey Ann} and Arter, {Olivia G.}",

note = "Funding Information: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Samuel M. Brown reports personal fees from Hamilton ventilators, and grants from the National Institutes of Health (NIH) and the U.S. Department of Defense (DoD). Jonathan D. Casey reports grants from the NIH and DoD. Steven Y. Chang was a speaker for La Jolla Pharmaceuticals in 2018, consulted for PureTech Health in 2020, and consulted for Kiniska Pharmaceuticals in December 2021. David J. Douin reports a grant from NIH/National Institute of General Medical Sciences. Abhijit Duggal reports grants from NIH and participation on a Steering Committee for ALungTechnologies. Matthew C. Exline reports support from Abbott Labs for sponsored talks. D. Clark Files reports personal consultant fees from Cytovale and membership on a data and safety monitoring board (DSMB) from Medpace. Anne E. Frosch reports grants from NIH/National Institute of Allergy and Infectious Diseases (NIAID), NIH/National Heart, Lung, and Blood Institute (NHLBI), and NIH/INSIGHT/ICC. Manjusha Gaglani reports grants from Abt Associates, Westat, and Janssen. Adit A. Ginde reports grants from NIH, DoD, AbbVie, and Faron Pharmaceuticals. Michelle N. Gong reports grants from NIH and the Agency for Healthcare Research and Quality (AHRQ), and DSMB membership fees from Regeneron, outside the submitted work. Carlos G. Grijalva reports consultancy fees from Pfizer, Merck, and Sanofi-Pasteur; grants from Campbell Alliance/Syneos Health, NIH, the Food and Drug Administration, AHRQ, and Sanofi. David N. Hager reports grants from NIH/NHLBI. Natasha Halasa reports grants and nonfinancial support from Sanofi, and grants from Quidel and NIH. Nicholas J. Johnson reports grants from NIH, DoD, and Medic One Foundation. Akram Khan reports grants from United Therapeutics, Johnson & Johnson, and Eli Lilly. Jennie H. Kwon reports grants from NIH/NIAID. Adam S. Lauring reports personal fees from Sanofi and Roche, and grants from NIH and Burroughs Wellcome Fund. Christopher J. Lindsell reports grants from NIH, DoD, and the Marcus Foundation; contract fees from bioMerieux, Endpoint Health, Entegrion Inc, and AbbVie; and a patent for risk stratification in sepsis and septic shock. Emily T. Martin reports grants from Merck. Arnold S. Monto reports a grant from NIH. Ithan D. Peltan reports grants from NIH, Janssen Pharmaceuticals, and Intermountain Research and Medical Foundation, and institutional support from Asahi Kasei Pharma and Regeneron. Todd W. Rice reports grants from NIH, DoD, and AbbVie and personal fees from Cumberland Pharmaceuticals, Inc., and Cytovale, Inc. No other potential conflicts of interest were disclosed.",

year = "2022",

month = mar,

day = "25",

doi = "10.15585/MMWR.MM7112E1",

language = "English",

volume = "71",

pages = "459--465",

journal = "Morbidity and Mortality Weekly Report",

issn = "0149-2195",

number = "12",

}

TY - JOUR

T1 - Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022

AU - IVY Network

AU - Tenforde, Mark W.

AU - Self, Wesley H.

AU - Gaglani, Manjusha

AU - Ginde, Adit A.

AU - Douin, David J.

AU - Talbot, H. Keipp

AU - Casey, Jonathan D.

AU - Mohr, Nicholas M.

AU - Zepeski, Anne

AU - McNeal, Tresa

AU - Ghamande, Shekhar

AU - Gibbs, Kevin W.

AU - Files, D. Clark

AU - Hager, David N.

AU - Shehu, Arber

AU - Prekker, Matthew E.

AU - Frosch, Anne E.

AU - Gong, Michelle N.

AU - Mohamed, Amira

AU - Johnson, Nicholas J.

AU - Srinivasan, Vasisht

AU - Steingrub, Jay S.

AU - Peltan, Ithan D.

AU - Brown, Samuel M.

AU - Martin, Emily T.

AU - Monto, Arnold S.

AU - Khan, Akram

AU - Hough, Catherine L.

AU - Busse, Laurence W.

AU - Duggal, Abhijit

AU - Wilson, Jennifer G.

AU - Qadir, Nida

AU - Chang, Steven Y.

AU - Mallow, Christopher

AU - Rivas, Carolina

AU - Babcock, Hilary M.

AU - Kwon, Jennie H.

AU - Exline, Matthew C.

AU - Botros, Mena

AU - Lauring, Adam S.

AU - Shapiro, Nathan I.

AU - Halasa, Natasha

AU - Chappell, James D.

AU - Grijalva, Carlos G.

AU - Rice, Todd W.

AU - Jones, Ian D.

AU - Stubblefield, William B.

AU - Baughman, Adrienne

AU - Womack, Kelsey N.

AU - Rhoads, Jillian P.

AU - Lindsell, Christopher J.

AU - Hart, Kimberly W.

AU - Zhu, Yuwei

AU - Adams, Katherine

AU - Surie, Diya

AU - McMorrow, Meredith L.

AU - Patel, Manish M.

AU - Calhoun, Nicole

AU - Herrick, Judy

AU - Hoffman, Eric

AU - McKillop, Amanda

AU - Murthy, Kempapura

AU - Smith, Michael

AU - Zayed, Martha

AU - De Souza, Lesley

AU - Kindle, Ryan

AU - Kozikowski, Lori Ann

AU - Ouellette, Scott

AU - Thornton-Thompson, Sherell

AU - Bolstad, Michael

AU - Ciottone, Robert

AU - Coviello, Brianna

AU - Devilla, Arnaldo

AU - Grafals, Ana

AU - Higgins, Conor

AU - Ottanelli, Carlo

AU - Redman, Kimberly

AU - Scaffidi, Douglas

AU - Weingart, Alexander

AU - Lewis, Nathaniel

AU - Olson, Samantha

AU - Ashok, Kiran

AU - Brennan, Connery

AU - Mehkri, Omar

AU - Mitchell, Megan

AU - Poynter, Bryan

AU - Stanley, Nicholas

AU - ten Lohuis, Caitlin

AU - Caspers, Sean

AU - Erikson, Heidi

AU - Hendrickson, Audrey

AU - Kaus, Olivia

AU - Maruggi, Ellen

AU - Scharber, Tyler

AU - Tordsen, Walker

AU - Aston, Valerie

AU - Bowers, Robert

AU - Jorgensen, Jeffrey

AU - King, Jennifer

AU - Ali, Harith

AU - Rothman, Richard E.

AU - Nair, Rahul

AU - Chen, Jen Ting

AU - Karow, Sarah

AU - Robart, Emily

AU - Maldonado, Paulo Nunes

AU - Khan, Maryiam

AU - So, Preston

AU - Schwartz, Elizabeth

AU - So, Madison

AU - Weigand, Michael

AU - Luong, Andrea

AU - Martinez, Jesus

AU - Huynh, Bao

AU - Ibrahim, Habiba

AU - Villanueva-Vargas, Cynthia

AU - Jung, Haeun

AU - Villanueva-Vargas, Juliana

AU - Quadri, Suha

AU - Gordon, Jun

AU - Levitt, Joe

AU - Perez, Cynthia

AU - Visweswaran, Anita

AU - Roque, Jonasel

AU - Rivera, Adreanne

AU - Frankel, Trevor

AU - Goff, Jennifer

AU - Huynh, David

AU - Jensen, Kelly

AU - Driver, Conner

AU - Chambers, Ian

AU - Nassar, Paul

AU - Stout, Lori

AU - Sibenaller, Zita

AU - Walter, Alicia

AU - Mares, Jasmine

AU - Olson, Logan

AU - Clinansmith, Bradley

AU - Gershengorn, Hayley

AU - Rivas, Carolina

AU - McSpadden, E. J.

AU - Truscon, Rachel

AU - Kaniclides, Anne

AU - Thomas, Lara

AU - Bielak, Ramsay

AU - Valvano, Weronika Damek

AU - Fong, Rebecca

AU - Fitzsimmons, William J.

AU - Blair, Christopher

AU - Valesano, Andrew

AU - Baker, Leigh

AU - Gilbert, Julie

AU - Crider, Christine D.

AU - Steinbock, Kyle A.

AU - Paulson, Thomas C.

AU - Anderson, Layla A.

AU - Kampe, Christy

AU - Johnson, Jakea

AU - Short, Laura L.

AU - Ezzell, Lauren J.

AU - Whitsett, Margaret E.

AU - McHenry, Rendie E.

AU - Hargrave, Samarian J.

AU - Blair, Marica

AU - Luther, Jennifer L.

AU - Pulido, Claudia Guevara

AU - Peterson, Bryan P.M.

AU - LaRose, Mary

AU - Landreth, Leigha

AU - Hicks, Madeline

AU - Parks, Lisa

AU - Bongu, Jahnavi

AU - McDonald, David

AU - Cass, Candice

AU - Seiler, Sondra

AU - Park, David

AU - Hink, Tiffany

AU - Wallace, Meghan

AU - Burnham, Carey Ann

AU - Arter, Olivia G.

N1 - Funding Information: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Samuel M. Brown reports personal fees from Hamilton ventilators, and grants from the National Institutes of Health (NIH) and the U.S. Department of Defense (DoD). Jonathan D. Casey reports grants from the NIH and DoD. Steven Y. Chang was a speaker for La Jolla Pharmaceuticals in 2018, consulted for PureTech Health in 2020, and consulted for Kiniska Pharmaceuticals in December 2021. David J. Douin reports a grant from NIH/National Institute of General Medical Sciences. Abhijit Duggal reports grants from NIH and participation on a Steering Committee for ALungTechnologies. Matthew C. Exline reports support from Abbott Labs for sponsored talks. D. Clark Files reports personal consultant fees from Cytovale and membership on a data and safety monitoring board (DSMB) from Medpace. Anne E. Frosch reports grants from NIH/National Institute of Allergy and Infectious Diseases (NIAID), NIH/National Heart, Lung, and Blood Institute (NHLBI), and NIH/INSIGHT/ICC. Manjusha Gaglani reports grants from Abt Associates, Westat, and Janssen. Adit A. Ginde reports grants from NIH, DoD, AbbVie, and Faron Pharmaceuticals. Michelle N. Gong reports grants from NIH and the Agency for Healthcare Research and Quality (AHRQ), and DSMB membership fees from Regeneron, outside the submitted work. Carlos G. Grijalva reports consultancy fees from Pfizer, Merck, and Sanofi-Pasteur; grants from Campbell Alliance/Syneos Health, NIH, the Food and Drug Administration, AHRQ, and Sanofi. David N. Hager reports grants from NIH/NHLBI. Natasha Halasa reports grants and nonfinancial support from Sanofi, and grants from Quidel and NIH. Nicholas J. Johnson reports grants from NIH, DoD, and Medic One Foundation. Akram Khan reports grants from United Therapeutics, Johnson & Johnson, and Eli Lilly. Jennie H. Kwon reports grants from NIH/NIAID. Adam S. Lauring reports personal fees from Sanofi and Roche, and grants from NIH and Burroughs Wellcome Fund. Christopher J. Lindsell reports grants from NIH, DoD, and the Marcus Foundation; contract fees from bioMerieux, Endpoint Health, Entegrion Inc, and AbbVie; and a patent for risk stratification in sepsis and septic shock. Emily T. Martin reports grants from Merck. Arnold S. Monto reports a grant from NIH. Ithan D. Peltan reports grants from NIH, Janssen Pharmaceuticals, and Intermountain Research and Medical Foundation, and institutional support from Asahi Kasei Pharma and Regeneron. Todd W. Rice reports grants from NIH, DoD, and AbbVie and personal fees from Cumberland Pharmaceuticals, Inc., and Cytovale, Inc. No other potential conflicts of interest were disclosed.

PY - 2022/3/25

Y1 - 2022/3/25

UR - http://www.scopus.com/inward/record.url?scp=85127043344&partnerID=8YFLogxK

U2 - 10.15585/MMWR.MM7112E1

DO - 10.15585/MMWR.MM7112E1

M3 - Article

C2 - 35324878

AN - SCOPUS:85127043344

SN - 0149-2195

VL - 71

SP - 459

EP - 465

JO - Morbidity and Mortality Weekly Report

JF - Morbidity and Mortality Weekly Report

IS - 12

ER -

Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022

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