Effective treatment of chronic radiation proctitis using radiofrequency ablation

Chao Zhou, Desmond C. Adler, Yu Chen, Tsung Han Tsai, James G. Fujimoto, Laren Becker, Marisa Figueiredo, Hiroshi Mashimo, Joseph M. Schmitt

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71 Scopus citations


Endoscopic argon plasma coagulation and bipolar electrocautery are currently preferred treatments for chronic radiation proctitis, but ulcerations and strictures frequently occur. Radiofrequency ablation (RFA) has been successful for mucosal ablation in the esophagus. Here we report the efficacy of RFA with the BarRx Halo90 system in three patients with bleeding from chronic radiation proctitis. In all cases, the procedure was well tolerated and hemostasis was achieved after 1 or 2 RFA sessions. Re-epithelialization of squamous mucosa was observed over areas of prior hemorrhage. No stricturing or ulceration was seen on follow-up up to 19 months after RFA treatment. Real-time endoscopic optical coherence tomography (EOCT) visualized epithelialization and subsurface tissue microvasculature pre- and post-treatment, demonstrating its potential for follow-up assessment of endoscopic therapies.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalTherapeutic Advances in Gastroenterology
Issue number3
StatePublished - May 2009


  • Chronic radiation proctitis
  • Endoscopic optical coherence tomography (EOCT)
  • Endoscopic therapy
  • Lower gastrointestinal bleeding
  • Radiofrequency ablation (RFA)


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