Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2

Yoel Sadovsky, D. Michael Nelson, Louis J. Muglia, Gilad A. Gross, Katherine C. Harris, Alane Koki, Jaime L. Masferrer, Lisa M. Olson

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

OBJECTIVE: Cyclooxygenase inhibitors are effective tocolytic agents, but significant adverse effects limit their use. We hypothesized that selective inhibitors of the isozyme cyclooxygenase 2 would effectively diminish labor- associated prostaglandin production. STUDY DESIGN: We analyzed cyclooxygenase type 1 and 2 expression in amnion, chorion, decidua, and myometrium from laboring or nonlaboring women and tested the efficacy of selective cyclooxygenase 2 inhibition in diminishing prostaglandin production. RESULTS: The expression of cyclooxygenase 2 in amnion from women in labor, either preterm or at term, was significantly higher than in amnion before labor. In contrast, cyclooxygenase 1 expression was unchanged by labor. The enhanced expression of amniotic cyclooxygenase 2 was associated with increased prostaglandin E2 levels in laboring women. Amniotic prostaglandin E2 production was effectively diminished by the selective cyclooxygenase 2 inhibitors SC-236 and NS-398 but not by the cyclooxygenase 1 inhibitor SC- 560. CONCLUSION: Selective inhibitors of cyclooxygenase 2 are effective in diminishing prostaglandin production in vitro and may be useful in prevention of preterm deliveries.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalAmerican journal of obstetrics and gynecology
Volume182
Issue number2
DOIs
StatePublished - Jan 1 2000

Keywords

  • Amnion
  • Cyclooxygenase
  • Cyclooxygenase inhibitors
  • Labor
  • Prostaglandin E

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