TY - JOUR
T1 - Effective connectivity inferred from fMRI transition dynamics during movie viewing points to a balanced reconfiguration of cortical interactions
AU - Gilson, Matthieu
AU - Deco, Gustavo
AU - Friston, Karl J.
AU - Hagmann, Patric
AU - Mantini, Dante
AU - Betti, Viviana
AU - Romani, Gian Luca
AU - Corbetta, Maurizio
N1 - Funding Information:
This work was supported by the European Union's Horizon 2020 research and innovation programme / Human Brain Project (grant FP7-FET-ICT-604102 to MG and GD; H2020-720270 HBP SGA1 to GD) and the Marie Sklodowska-Curie Action (grant H2020-MSCA-656547 to MG). GD also acknowledges funding from the ERC Advanced Grant DYSTRUCTURE ( #295129 ) and the Spanish Research Project PSI2016-75688-P . DM was supported by the KU Leuven Special Research Fund (grant C16/15/070 ). KJF is funded by a Wellcome Trust Principal Research Fellowship (Ref: 088130/Z/09/Z ). MC was supported by the National Institute of Mental Health (grant MH109429 ). PH was supported by the Leenaards Foundation .
Publisher Copyright:
© 2017
PY - 2018/10/15
Y1 - 2018/10/15
N2 - Our behavior entails a flexible and context-sensitive interplay between brain areas to integrate information according to goal-directed requirements. However, the neural mechanisms governing the entrainment of functionally specialized brain areas remain poorly understood. In particular, the question arises whether observed changes in the regional activity for different cognitive conditions are explained by modifications of the inputs to the brain or its connectivity? We observe that transitions of fMRI activity between areas convey information about the tasks performed by 19 subjects, watching a movie versus a black screen (rest). We use a model-based framework that explains this spatiotemporal functional connectivity pattern by the local variability for 66 cortical regions and the network effective connectivity between them. We find that, among the estimated model parameters, movie viewing affects to a larger extent the local activity, which we interpret as extrinsic changes related to the increased stimulus load. However, detailed changes in the effective connectivity preserve a balance in the propagating activity and select specific pathways such that high-level brain regions integrate visual and auditory information, in particular boosting the communication between the two brain hemispheres. These findings speak to a dynamic coordination underlying the functional integration in the brain.
AB - Our behavior entails a flexible and context-sensitive interplay between brain areas to integrate information according to goal-directed requirements. However, the neural mechanisms governing the entrainment of functionally specialized brain areas remain poorly understood. In particular, the question arises whether observed changes in the regional activity for different cognitive conditions are explained by modifications of the inputs to the brain or its connectivity? We observe that transitions of fMRI activity between areas convey information about the tasks performed by 19 subjects, watching a movie versus a black screen (rest). We use a model-based framework that explains this spatiotemporal functional connectivity pattern by the local variability for 66 cortical regions and the network effective connectivity between them. We find that, among the estimated model parameters, movie viewing affects to a larger extent the local activity, which we interpret as extrinsic changes related to the increased stimulus load. However, detailed changes in the effective connectivity preserve a balance in the propagating activity and select specific pathways such that high-level brain regions integrate visual and auditory information, in particular boosting the communication between the two brain hemispheres. These findings speak to a dynamic coordination underlying the functional integration in the brain.
UR - http://www.scopus.com/inward/record.url?scp=85031820609&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2017.09.061
DO - 10.1016/j.neuroimage.2017.09.061
M3 - Review article
C2 - 29024792
AN - SCOPUS:85031820609
SN - 1053-8119
VL - 180
SP - 534
EP - 546
JO - NeuroImage
JF - NeuroImage
ER -