Effect of weight loss on the retinochoroidal structural alterations among patients with exogenous obesity

Aniruddha Agarwal, Arshiya Saini, Sarakshi Mahajan, Rupesh Agrawal, Carol Y. Cheung, Ashu Rastogi, Rajesh Gupta, Yu Meng Wang, Michael Kwan, Vishali Gupta

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Purpose To evaluate the changes in the retinochoroidal vasculature in patients with exogenous obesity using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). Methods In this prospective study, 60 patients diagnosed with obesity (47 males) (mean age: 46.47 ±10.9 years) were included, of which 30 patients underwent bariatric surgery (Group A), and 30 patients underwent conservative management (exercise/diet) (Group B). Parameters including choroidal thickness (CT), choroidal vascularity index (CVI) and retinal capillary density index (CDI) and arteriovenous ratio (AVR) were measured at the baseline and three months follow up. 30 eyes (30 age and gender-matched) of normal participants were included for comparison. Results Baseline CT was lower in 60 participants with obesity compared to controls. Compared with normal subjects, subjects with obesity had higher mean CVI (0.66±0.02 versus 0.63±0.04; p<0.01), smaller FAZ area (0.26±0.07 versus 0.45±0.32; p<0.01), higher CDI (superficial plexus: 0.7±0.04 versus 0.68±0.06; p = 0.04, deep plexus: 0.38±0.02 versus 0.35±0.06; p = 0.01), and lower AVR (0.68±0.05 versus 0.70±0.03 versus; p<0.01). At 3-month after intervention, CT showed a significant increase in participants from Group A (329.27±79μm; p<0.01) but not in Group B from baseline. No significant change was noted in CVI or CDI at 3-month in either group compared to baseline. AVR significantly increased in Group B (p = 0.03). Conclusion Subclinical changes in retinochoroidal vasculature occurs in participants with exogenous obesity compared to healthy subjects. Surgical intervention (bariatric surgery) may have a favorable outcome on the choroidal thickness in these patients.

Original languageEnglish
Article numbere0235926
JournalPloS one
Volume15
Issue number7 July
DOIs
StatePublished - Jul 2020

Fingerprint

Dive into the research topics of 'Effect of weight loss on the retinochoroidal structural alterations among patients with exogenous obesity'. Together they form a unique fingerprint.

Cite this