Effect of triolein infusion IITH or IITHout phosphatidylchol' -K on intestinal alkaline phosphatase activity and lipid levels in rat serum

T. Irino, M. Matsushua, T. Nakajima, S. Hokari, T. Koboda, D. H. Alpers

Research output: Contribution to journalArticle

Abstract

The aim of this study was lo examine the offerts of trinlein feeding versus triolt-in plus phosphat idy Ichol me (PC) feeding on ral serum triacyIglycerol (T(0 and phospholipid contents and on intestinal alkaline phosphaiase (IAP) activity, Following tnoleiti feeding IAP activity, and serum T(! and phosphol ipid levels increased 114%, 93% and 33%, respectively, compared with fasted controls. Triolein plus PC, on the other hand, was associated with increases in serum levels of 63%, 285%, and 52%, respectively, compared wilh fasted controls. Infusion of triolein and IT predominant l v induced very low density lipopro tcin in rat enterocyles. There was evidence thai both serum TC nid phospholipid levels were higher after mixed infusion of triolein plus PC than after infusion of triolein alone, but IAP activity with the mixed infusion was lower than with triolcin alone. In addition, the secretion of a phospholi p id rich mem braue 'surfactant Iike particles) was consistent with secret ion of IAP II and/or chylomicrons bv enterocytes.

Original languageEnglish
Pages (from-to)A1017
JournalFASEB Journal
Volume11
Issue number9
StatePublished - Dec 1 1997

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