Effect of testosterone therapy on bone formation in an osteoporotic hypogonadal male

Daniel T. Baran, Michele A. Bergfeld, Steven L. Teitelbaum, Louis V. Avioli

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

Osteoporosis has been reported to complicate androgen deficiency in males. Accordingly, we have evaluated an osteoporotic hypogonadal male with bone histomorphometry before and after 6 months of testosterone replacement. Androgen therapy resulted in increases in relative osteoid volum, total osteoid surface, linear extent of bone formation, and bone mineralization. The dramatic histological response to hormonal replacement confirms the importance of androgens in bone modeling and remodeling.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalCalcified Tissue Research
Volume26
Issue number1
DOIs
StatePublished - Dec 1 1978

Keywords

  • Bone formation
  • Hypogonadism
  • Osteoporosis
  • Testosterone

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