TY - JOUR
T1 - Effect of subthalamic deep brain stimulation on turning kinematics and related saccadic eye movements in Parkinson disease
AU - Lohnes, Corey A.
AU - Earhart, Gammon M.
N1 - Funding Information:
We thank Marie McNeely for assistance with data collection, Brian Morrell for assistance with data processing, and Dr. Richard Abrams for assistance with project design and pilot testing. This publication was made possible by R01 HD056015 , the Barnes Jewish Hospital Foundation , and grant number UL1 RR024992 from the National Center for Research Resources (NCRR) , a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Additional support came from the St. Louis Chapter of the American Parkinson Disease Association (APDA) and the APDA Advanced Center for PD Research at Washington University in St. Louis .
PY - 2012/8
Y1 - 2012/8
N2 - Background: Persons with Parkinson disease (PD) experience turning difficulty, often leading to freezing of gait and falls. Visual information plays a significant role in locomotion and turning, and while the effects of deep brain stimulation (DBS) on oculomotor function have been well documented, the effects of DBS on oculomotor function during turning and on turning itself have yet to be fully elucidated. Objective: To determine the effects of STN DBS on turning performance and related oculomotor performance in PD. Methods: Eleven subjects with PD and DBS of the subthalamic nucleus performed a seated voluntary saccade task and standing 180° turns in DBS OFF and DBS ON conditions. Oculomotor data were captured using an infrared eye tracking system while segment rotations were measured using 3-D motion capture. Results: During the seated saccade task, DBS did not improve saccade amplitude or latency. DBS also did not improve gait velocity and stride length during forward walking. During turning, DBS improved turn performance (turn duration), reduced the number of saccades performed during the turns, and increased the amplitude and velocity of the saccade initiating the turn. DBS decreased the intersegmental latencies (eye-head, eye-foot, and head-trunk) but this effect was lost for eye-head and eye-foot after controlling for the duration of the first gait cycle. Conclusions: DBS significantly improves turn performance and related oculomotor performance. These findings add to the growing list of therapeutic benefits offered by DBS.
AB - Background: Persons with Parkinson disease (PD) experience turning difficulty, often leading to freezing of gait and falls. Visual information plays a significant role in locomotion and turning, and while the effects of deep brain stimulation (DBS) on oculomotor function have been well documented, the effects of DBS on oculomotor function during turning and on turning itself have yet to be fully elucidated. Objective: To determine the effects of STN DBS on turning performance and related oculomotor performance in PD. Methods: Eleven subjects with PD and DBS of the subthalamic nucleus performed a seated voluntary saccade task and standing 180° turns in DBS OFF and DBS ON conditions. Oculomotor data were captured using an infrared eye tracking system while segment rotations were measured using 3-D motion capture. Results: During the seated saccade task, DBS did not improve saccade amplitude or latency. DBS also did not improve gait velocity and stride length during forward walking. During turning, DBS improved turn performance (turn duration), reduced the number of saccades performed during the turns, and increased the amplitude and velocity of the saccade initiating the turn. DBS decreased the intersegmental latencies (eye-head, eye-foot, and head-trunk) but this effect was lost for eye-head and eye-foot after controlling for the duration of the first gait cycle. Conclusions: DBS significantly improves turn performance and related oculomotor performance. These findings add to the growing list of therapeutic benefits offered by DBS.
KW - Deep brain stimulation
KW - Oculomotor dysfunction
KW - Parkinson disease
KW - Saccades
KW - Turning
UR - http://www.scopus.com/inward/record.url?scp=84863445033&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2012.05.001
DO - 10.1016/j.expneurol.2012.05.001
M3 - Article
C2 - 22580213
AN - SCOPUS:84863445033
SN - 0014-4886
VL - 236
SP - 389
EP - 394
JO - Experimental Neurology
JF - Experimental Neurology
IS - 2
ER -