TY - GEN
T1 - Effect of shockwaves on the biomechanical and biochemical function of cells
AU - Barthel, James
AU - Konkar, Samidha
AU - Sankin, Georgy
AU - Darling, Eric
AU - Guilak, Farshid
AU - Zhong, Pei
AU - LaMattina, Bruce
AU - Zauscher, Stefan
PY - 2008/12/1
Y1 - 2008/12/1
N2 - The number of non-lethal cases of soldiers being exposed to blasts from improvised explosive devices (IED) has increased significantly over the last few years. Concurrently, the number of soft tissue injuries, including traumatic brain injuries (TBI) and heterotopic ossification (HO, i.e., abnormal formation of bone in soft tissue) have increased. Little is known, however, about the molecular and cellular level effects of high strain-rate loading of soft tissues. Here we report on the instrumentation and procedures we have developed to apply high strain-rate loading to cell-sheets in vitro and we will discuss the biomechanical and biochemical properties of cells that have been exposed to high strain rate loading conditions.
AB - The number of non-lethal cases of soldiers being exposed to blasts from improvised explosive devices (IED) has increased significantly over the last few years. Concurrently, the number of soft tissue injuries, including traumatic brain injuries (TBI) and heterotopic ossification (HO, i.e., abnormal formation of bone in soft tissue) have increased. Little is known, however, about the molecular and cellular level effects of high strain-rate loading of soft tissues. Here we report on the instrumentation and procedures we have developed to apply high strain-rate loading to cell-sheets in vitro and we will discuss the biomechanical and biochemical properties of cells that have been exposed to high strain rate loading conditions.
UR - http://www.scopus.com/inward/record.url?scp=58049135880&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:58049135880
SN - 9781605604152
T3 - Society for Experimental Mechanics - 11th International Congress and Exhibition on Experimental and Applied Mechanics 2008
SP - 1315
EP - 1319
BT - Society for Experimental Mechanics - 11th International Congress and Exhibition on Experimental and Applied Mechanics 2008
T2 - 11th International Congress and Exhibition on Experimental and Applied Mechanics 2008
Y2 - 2 June 2008 through 5 June 2008
ER -