Effect of shockwaves on the biomechanical and biochemical function of cells

James Barthel, Samidha Konkar, Georgy Sankin, Eric Darling, Farshid Guilak, Pei Zhong, Bruce LaMattina, Stefan Zauscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The number of non-lethal cases of soldiers being exposed to blasts from improvised explosive devices (IED) has increased significantly over the last few years. Concurrently, the number of soft tissue injuries, including traumatic brain injuries (TBI) and heterotopic ossification (HO, i.e., abnormal formation of bone in soft tissue) have increased. Little is known, however, about the molecular and cellular level effects of high strain-rate loading of soft tissues. Here we report on the instrumentation and procedures we have developed to apply high strain-rate loading to cell-sheets in vitro and we will discuss the biomechanical and biochemical properties of cells that have been exposed to high strain rate loading conditions.

Original languageEnglish
Title of host publicationSociety for Experimental Mechanics - 11th International Congress and Exhibition on Experimental and Applied Mechanics 2008
Pages1315-1319
Number of pages5
StatePublished - Dec 1 2008
Event11th International Congress and Exhibition on Experimental and Applied Mechanics 2008 - Orlando, FL, United States
Duration: Jun 2 2008Jun 5 2008

Publication series

NameSociety for Experimental Mechanics - 11th International Congress and Exhibition on Experimental and Applied Mechanics 2008
Volume3

Conference

Conference11th International Congress and Exhibition on Experimental and Applied Mechanics 2008
CountryUnited States
CityOrlando, FL
Period06/2/0806/5/08

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    Barthel, J., Konkar, S., Sankin, G., Darling, E., Guilak, F., Zhong, P., LaMattina, B., & Zauscher, S. (2008). Effect of shockwaves on the biomechanical and biochemical function of cells. In Society for Experimental Mechanics - 11th International Congress and Exhibition on Experimental and Applied Mechanics 2008 (pp. 1315-1319). (Society for Experimental Mechanics - 11th International Congress and Exhibition on Experimental and Applied Mechanics 2008; Vol. 3).