There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalRejuvenation Research
Issue number1
StatePublished - Feb 1 2008


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