Abstract
There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 177-185 |
| Number of pages | 9 |
| Journal | Rejuvenation Research |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2008 |