Effect of senescence on macrophage polarization and angiogenesis

Dru S. Dace, Rajendra S. Apte

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalRejuvenation Research
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2008

Fingerprint

Dive into the research topics of 'Effect of senescence on macrophage polarization and angiogenesis'. Together they form a unique fingerprint.

Cite this