TY - JOUR
T1 - Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength
T2 - A Randomized Controlled Study
AU - Smith, Gordon I.
AU - Commean, Paul K.
AU - Reeds, Dominic N.
AU - Klein, Samuel
AU - Mittendorfer, Bettina
N1 - Funding Information:
The authors thank Janet Winkelmann, Rachel Burrows, Sophie Julliand, Lynda Bowers, and Kathryn Gratza for help with subject recruitment, scheduling, and testing; the staff of the Clinical Research Unit and Metabolic Kitchen for their help in performing the studies; and the study subjects for their participation.
Funding Information:
See Commentary, pg. 789. Funding agencies: This publication was made possible by NIH grants DK 94483, DK 56341 (Nutrition and Obesity Research Center), DK 20579 (Diabetes Research Center), DK 52574 (Digestive Disease Research Center), and UL1 TR000448 (Clinical Translational Science Award, including KL2 subaward TR 000450) and by support from the Atkins and Pershing Square Foundations. Disclosure: The authors declared no conflict of interest. Author contributions: BM and SK designed the study; GIS, PKC, DNR, SK, and BM conducted the study; GIS and BM analyzed the data; GIS and BM drafted the manuscript; PKC, DNR, and SK critically revised the manuscript for important intellectual content; DNR and SK provided medical supervision for the study; BM was responsible for overall study supervision and had primary responsibility for the final content. All authors read and approved the final manuscript. Clinical trial registration: ClinicalTrials.gov identifier NCT01538836. Additional Supporting Information may be found in the online version of this article. Received: 2 November 2017; Accepted: 19 February 2018; Published online 24 April 2018. doi:10.1002/oby.22169
Publisher Copyright:
© 2018 The Obesity Society
PY - 2018/5
Y1 - 2018/5
N2 - Objective: High protein (particularly leucine-rich whey protein) intake is recommended to mitigate the adverse effect of weight loss on muscle mass. The effectiveness of this approach is unknown. Methods: Seventy middle-aged (50-65 years old) postmenopausal women with obesity were randomized to (1) weight maintenance (WM), (2) weight loss and the recommended daily allowance for protein (0.8 g/kg/d) (WL group), or (3) weight loss plus whey protein supplementation (total protein: 1.2 g/kg/d) (WL-PS group). Thigh muscle volume and strength were assessed at baseline and after 5% and 10% weight loss in the weight-loss groups and after matched time periods (∼3 and 6 months, respectively) in the WM group. Results: A 5% weight loss caused a greater decrease in thigh muscle volume in the WL group than the WL-PS group (4.7% ± 0.7% vs. 2.8% ± 0.8%, respectively; P < 0.05). After 10% weight loss, there was no statistically significant difference in muscle mass loss in the two groups, and the total loss was small in both groups (5.5% ± 0.8% and 4.5% ± 0.7%, respectively). The dietary interventions did not affect muscle strength. Conclusions: Whey protein supplementation during diet-induced weight loss does not have clinically important therapeutic effects on muscle mass or strength in middle-aged postmenopausal women with obesity.
AB - Objective: High protein (particularly leucine-rich whey protein) intake is recommended to mitigate the adverse effect of weight loss on muscle mass. The effectiveness of this approach is unknown. Methods: Seventy middle-aged (50-65 years old) postmenopausal women with obesity were randomized to (1) weight maintenance (WM), (2) weight loss and the recommended daily allowance for protein (0.8 g/kg/d) (WL group), or (3) weight loss plus whey protein supplementation (total protein: 1.2 g/kg/d) (WL-PS group). Thigh muscle volume and strength were assessed at baseline and after 5% and 10% weight loss in the weight-loss groups and after matched time periods (∼3 and 6 months, respectively) in the WM group. Results: A 5% weight loss caused a greater decrease in thigh muscle volume in the WL group than the WL-PS group (4.7% ± 0.7% vs. 2.8% ± 0.8%, respectively; P < 0.05). After 10% weight loss, there was no statistically significant difference in muscle mass loss in the two groups, and the total loss was small in both groups (5.5% ± 0.8% and 4.5% ± 0.7%, respectively). The dietary interventions did not affect muscle strength. Conclusions: Whey protein supplementation during diet-induced weight loss does not have clinically important therapeutic effects on muscle mass or strength in middle-aged postmenopausal women with obesity.
UR - http://www.scopus.com/inward/record.url?scp=85045735754&partnerID=8YFLogxK
U2 - 10.1002/oby.22169
DO - 10.1002/oby.22169
M3 - Article
C2 - 29687650
AN - SCOPUS:85045735754
SN - 1930-7381
VL - 26
SP - 854
EP - 861
JO - Obesity
JF - Obesity
IS - 5
ER -