Effect of prostaglandin E1 on the adenyl cyclase-cyclic AMP system and gluconeogenesis in rat renal cortical slices

Aubrey R. Morrison, Jesse Yates, Saulo Klahr

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Prostaglandin E1 was found to increase the formation of cyclic adenosine 3t́,5t́-monophosphate (cyclic AMP) by renal cortical slices. This increased release of cyclic AMP was not influenced by the absence of Ca2+ in the incubating media. The enhanced production of cyclic AMP was probably mediated by stimulation of membrane-bound adenylate cyclase activity. An increase in adenyl cyclase activity was observed with increasing concentrations of prostaglandin E1. Furthermore, prostaglandin E1 augmented glucose production from α-ketoglutarate. This effect on gluconeogenesis was abolished by the removal of Ca2+ from the incubating medium. These effects are similar to those described for parathyroid hormone and suggest that the renal cortex is a prostaglandin-dependent system. Prostaglandin E1 decreased cyclic AMP production and glucose production (from α-ketoglutarate) in response to submaximal doses of parathyroid hormone, suggesting that prostaglandin may be important in modulating the intracellular action of parathyroid hormone in the kidney cortex.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalBBA - General Subjects
Volume421
Issue number2
DOIs
StatePublished - Feb 24 1976

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