TY - JOUR
T1 - Effect of prolonged intense endurance training on systolic time intervals in patients with coronary artery disease
AU - Martin, Wade H.
AU - Heath, Gregory
AU - Coyle, Edward F.
AU - Bloomfield, Susan A.
AU - Holloszy, John O.
AU - Ehsani, Ali A.
N1 - Funding Information:
From the Division of Applied Physiology, Irene Walter Johnson Institute of Rehabilitation, Department of Preventive Medicine and Cardiovascular Division, Department of Medicine, Washington University School of Medicine. Supported by National Institutes of Health research grant HL22215. Dr. Martin is a postdoctoral research trainee supported by NIH training grant AM07226 Dr. Heath was a postdoctoral research trainee supported by NIH training grant HL07081. Dr. Coyle was a postdoctoral research trainee initially supported by NIH training grant HL07081 and later by NIH training grant AG00078. Received for publication Feb. 3, 1982; revision received July 17, 1982; accepted July 23, 1982. Reprint requests: Ali A. Ehsani, M.D., Department of Preventive Medicine, Washington University School of Medicine, 4566 Scott Ave., St. Louis, MO 63110.
PY - 1984/1
Y1 - 1984/1
N2 - We studied the effect of exercise training (ET) on systolic time intervals (STI) in 13 patients with coronary artery disease (CAD). All patients trained for at least 10 months. They exercised three times/week at 50% to 70% of maximal oxygen uptake (V̇O2max) for the initial 3 months and at least four times/week for approximately 50 minutes at 70% to 90% of V̇O2max thereafter. A significant training effect was documented by an increase in V̇O2max from 26.0 ± 4.3 to 37.2 ± 5.8 ml/kg/min (p < 0.01), a lower heart rate (HR) at rest, and a lower blood pressure and HR during submaximal work. The indices of total electromechanical systole (QS2I) and left ventricular ejection time (LVETI) did not change. However, pre-ejection period index (PEPI) decreased from 137 ± 9 msec to 129 ± 9 msec (p < 0.01). PEP LVET decreased from 0.373 ± 0.028 to 0.342 ± 0.032 (p < 0.01). Left ventricular end-diastolic dimension and posterior wall thickness, measured echocardiographically, were increased after training. We conclude that exercise training may improve myocardial performance in some patients with CAD.
AB - We studied the effect of exercise training (ET) on systolic time intervals (STI) in 13 patients with coronary artery disease (CAD). All patients trained for at least 10 months. They exercised three times/week at 50% to 70% of maximal oxygen uptake (V̇O2max) for the initial 3 months and at least four times/week for approximately 50 minutes at 70% to 90% of V̇O2max thereafter. A significant training effect was documented by an increase in V̇O2max from 26.0 ± 4.3 to 37.2 ± 5.8 ml/kg/min (p < 0.01), a lower heart rate (HR) at rest, and a lower blood pressure and HR during submaximal work. The indices of total electromechanical systole (QS2I) and left ventricular ejection time (LVETI) did not change. However, pre-ejection period index (PEPI) decreased from 137 ± 9 msec to 129 ± 9 msec (p < 0.01). PEP LVET decreased from 0.373 ± 0.028 to 0.342 ± 0.032 (p < 0.01). Left ventricular end-diastolic dimension and posterior wall thickness, measured echocardiographically, were increased after training. We conclude that exercise training may improve myocardial performance in some patients with CAD.
UR - http://www.scopus.com/inward/record.url?scp=0021334722&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(84)90136-4
DO - 10.1016/0002-8703(84)90136-4
M3 - Article
C2 - 6691243
AN - SCOPUS:0021334722
VL - 107
SP - 75
EP - 81
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1
ER -