TY - JOUR
T1 - Effect of progesterone on serotonin turnover in rats primed with estrogen implants into the ventromedial hypothalamus
AU - Gereau IV, Robert W.
AU - Kedzie, Kathleen A.
AU - Renner, Kenneth J.
PY - 1993
Y1 - 1993
N2 - The effect of progesterone (P) on serotonin (5-HT) turnover was studied in nine brain regions in ovariectomized rats primed with bilateral intracerebral implants of estradiol benzoate (1:250 cholesterol) directed towards the ventromedial hypothalamus (VMN). Two days after surgery, animals received P (0.5 mg SC), and were pretested for lordosis behavior. After a 44-h recovery period, rats with LQ ≥60 were randomly divided into groups that received either a second behavior test or IP injections of saline or pargyline (4 h after P or V). P treatment decreased pargyline-induced accumulation of 5-HT in the VMN (pars lateralis), the lateral midbrain central grey (IMCG), and the periventricular region (PVE, anterior hypothalamic region). The 5-HIAA/5-HT ratios were significantly decreased in the VMN and PVE in P-treated animals. These results support the hypothesis that P-influenced decreases in serotonergic activity in the VMN contribute to the facilitation of female receptivity, and also suggest that steroid-mediated actions in the VMN may lead to changes in serotonergic activity in the IMCG and PVE.
AB - The effect of progesterone (P) on serotonin (5-HT) turnover was studied in nine brain regions in ovariectomized rats primed with bilateral intracerebral implants of estradiol benzoate (1:250 cholesterol) directed towards the ventromedial hypothalamus (VMN). Two days after surgery, animals received P (0.5 mg SC), and were pretested for lordosis behavior. After a 44-h recovery period, rats with LQ ≥60 were randomly divided into groups that received either a second behavior test or IP injections of saline or pargyline (4 h after P or V). P treatment decreased pargyline-induced accumulation of 5-HT in the VMN (pars lateralis), the lateral midbrain central grey (IMCG), and the periventricular region (PVE, anterior hypothalamic region). The 5-HIAA/5-HT ratios were significantly decreased in the VMN and PVE in P-treated animals. These results support the hypothesis that P-influenced decreases in serotonergic activity in the VMN contribute to the facilitation of female receptivity, and also suggest that steroid-mediated actions in the VMN may lead to changes in serotonergic activity in the IMCG and PVE.
KW - Estrogen implants
KW - Lordosis
KW - Midbrain central grey
KW - Serotonin
KW - Systemic progesterone
KW - Ventromedial hypothalamus
UR - http://www.scopus.com/inward/record.url?scp=0027257411&partnerID=8YFLogxK
U2 - 10.1016/0361-9230(93)90190-M
DO - 10.1016/0361-9230(93)90190-M
M3 - Article
C2 - 7690679
AN - SCOPUS:0027257411
SN - 0361-9230
VL - 32
SP - 293
EP - 300
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 3
ER -