Effect of Potassium Canrenoate on Cardiac Functions and (Na+ + K+)-Activated ATPase

S. I. Baskin; T. Akera; C. R. Puckett; S. L. Brody; T. M. Brody

doi:10.3181/00379727-143-37351

Effect of Potassium Canrenoate on Cardiac Functions and (Na⁺ + K⁺)-Activated ATPase

S. I. Baskin
, T. Akera
, C. R. Puckett
, S. L. Brody
, T. M. Brody

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K⁺ ion. Potassium canrenoate did not inhibit (Na⁺ + K⁺)-ATPase nor did it modify the ouabain-enzyme interaction.

Original language	English
Pages (from-to)	495-498
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	143
Issue number	2
DOIs	https://doi.org/10.3181/00379727-143-37351
State	Published - Jun 1973

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title = "Effect of Potassium Canrenoate on Cardiac Functions and (Na+ + K+)-Activated ATPase",

abstract = "Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K+ ion. Potassium canrenoate did not inhibit (Na+ + K+)-ATPase nor did it modify the ouabain-enzyme interaction.",

author = "Baskin, \{S. I.\} and T. Akera and Puckett, \{C. R.\} and Brody, \{S. L.\} and Brody, \{T. M.\}",

year = "1973",

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T1 - Effect of Potassium Canrenoate on Cardiac Functions and (Na+ + K+)-Activated ATPase

AU - Baskin, S. I.

AU - Akera, T.

AU - Puckett, C. R.

AU - Brody, S. L.

AU - Brody, T. M.

PY - 1973/6

Y1 - 1973/6

N2 - Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K+ ion. Potassium canrenoate did not inhibit (Na+ + K+)-ATPase nor did it modify the ouabain-enzyme interaction.

AB - Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K+ ion. Potassium canrenoate did not inhibit (Na+ + K+)-ATPase nor did it modify the ouabain-enzyme interaction.

UR - https://www.scopus.com/pages/publications/0015631186

U2 - 10.3181/00379727-143-37351

DO - 10.3181/00379727-143-37351

M3 - Article

C2 - 4267771

AN - SCOPUS:0015631186

SN - 0037-9727

VL - 143

SP - 495

EP - 498

JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 2

ER -

Effect of Potassium Canrenoate on Cardiac Functions and (Na⁺ + K⁺)-Activated ATPase

Abstract

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