Effect of Potassium Canrenoate on Cardiac Functions and (Na+ + K+)-Activated ATPase

S. I. Baskin; T. Akera; C. R. Puckett; S. L. Brody; T. M. Brody

doi:10.3181/00379727-143-37351

Effect of Potassium Canrenoate on Cardiac Functions and (Na⁺ + K⁺)-Activated ATPase

S. I. Baskin, T. Akera, C. R. Puckett, S. L. Brody, T. M. Brody

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Abstract

Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K⁺ ion. Potassium canrenoate did not inhibit (Na⁺ + K⁺)-ATPase nor did it modify the ouabain-enzyme interaction.

Original language	English
Pages (from-to)	495-498
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	143
Issue number	2
DOIs	https://doi.org/10.3181/00379727-143-37351
State	Published - Jun 1973

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title = "Effect of Potassium Canrenoate on Cardiac Functions and (Na+ + K+)-Activated ATPase",

abstract = "Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K+ ion. Potassium canrenoate did not inhibit (Na+ + K+)-ATPase nor did it modify the ouabain-enzyme interaction.",

author = "Baskin, {S. I.} and T. Akera and Puckett, {C. R.} and Brody, {S. L.} and Brody, {T. M.}",

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T1 - Effect of Potassium Canrenoate on Cardiac Functions and (Na+ + K+)-Activated ATPase

AU - Baskin, S. I.

AU - Akera, T.

AU - Puckett, C. R.

AU - Brody, S. L.

AU - Brody, T. M.

PY - 1973/6

Y1 - 1973/6

N2 - Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K+ ion. Potassium canrenoate did not inhibit (Na+ + K+)-ATPase nor did it modify the ouabain-enzyme interaction.

AB - Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K+ ion. Potassium canrenoate did not inhibit (Na+ + K+)-ATPase nor did it modify the ouabain-enzyme interaction.

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AN - SCOPUS:0015631186

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JF - Proceedings of the Society for Experimental Biology and Medicine

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ER -

Effect of Potassium Canrenoate on Cardiac Functions and (Na⁺ + K⁺)-Activated ATPase

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