Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K+ ion. Potassium canrenoate did not inhibit (Na+ + K+)-ATPase nor did it modify the ouabain-enzyme interaction.
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jun 1973|