EFFECT OF PHOTOTHERAPY ON SISTER CHROMATID EXCHANGE IN PREMATURE INFANTS

Alan L. Schwartz; F. Sessions Cole; Frederick Fiedorek; Deborah Matthews; Inder Paika; Ivan D. Frantz; Samuel A. Latt

doi:10.1016/S0140-6736(78)91545-3

EFFECT OF PHOTOTHERAPY ON SISTER CHROMATID EXCHANGE IN PREMATURE INFANTS

Alan L. Schwartz, F. Sessions Cole, Frederick Fiedorek, Deborah Matthews, Inder Paika, Ivan D. Frantz, Samuel A. Latt

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	157-158
Number of pages	2
Journal	The Lancet
Volume	312
Issue number	8081
DOIs	https://doi.org/10.1016/S0140-6736(78)91545-3
State	Published - Jul 15 1978

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10.1016/S0140-6736(78)91545-3

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@article{1a007a1ad98a4b3fac1a3847437f41df,

title = "EFFECT OF PHOTOTHERAPY ON SISTER CHROMATID EXCHANGE IN PREMATURE INFANTS",

author = "Schwartz, {Alan L.} and {Sessions Cole}, F. and Frederick Fiedorek and Deborah Matthews and Inder Paika and Frantz, {Ivan D.} and Latt, {Samuel A.}",

note = "Funding Information: others. All patients were grade 3, 4, or 5 on the scale. They ranged in age from 4 to 80 years (mean 22). Coma was secondary to head injury in ten patients, hypoxia in four, and brain tumour, with prolonged postoperative unconsciousness, in two. All diagnoses were supported by angiography and/or computerised tomographic scanning. Patients with traumatic, acute epi- dural, subdural, or intracerebral hxmorrhage were excluded from the series. The first neurological examinations were done within 6 h of onset of coma and repeated daily. I.A.H.P. environmental enrichment programmes were started 12-24 h after admission to hospital, except in the two postoperative brain-tumour pa- tients whose programmes started 10 and 14 days after surgery. Follow-up has ranged from several days to 10 months. There have been no deaths. All sixteen patients have fully re- covered -from coma. Of twelve patients who have regained functional independence and are home, eight have reaquired their premorbid condition and have no detectable deficit. The other four, although still displaying some focal physical deficit or adaptive behaviour disorder, are recovering progressively. One patient, more recently admitted, is still in hospital. Two others, though alert, are in other institutions because of severe physical handicaps and lack of family to care for them. Of a comparable group of fourteen consecutive patients, also in severe coma (all grade 3-5 on the Glasgow scale), admitted to hospital during the previous 12-month period and followed up by one of us (M.D.D.), but not given programmes of en- vironmental enrichment, eleven died (79%). The improved outcome in the I.A.H.P.-managed warrants continuation of this study. This letter condenses two papers-The Child in Coma (E.B.L.) and Coma recovery (M.D.D.)-presented to the llth annual meeting of the World Organisation for Human Potential, cosponsored by the National Aeronautics and Space Administration/Ames Research Center and the Institutes for the Achievement of Human Potential, at Moffett Field, California, on May 18,1978.",

year = "1978",

month = jul,

day = "15",

doi = "10.1016/S0140-6736(78)91545-3",

language = "English",

volume = "312",

pages = "157--158",

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T1 - EFFECT OF PHOTOTHERAPY ON SISTER CHROMATID EXCHANGE IN PREMATURE INFANTS

AU - Schwartz, Alan L.

AU - Sessions Cole, F.

AU - Fiedorek, Frederick

AU - Matthews, Deborah

AU - Paika, Inder

AU - Frantz, Ivan D.

AU - Latt, Samuel A.

N1 - Funding Information: others. All patients were grade 3, 4, or 5 on the scale. They ranged in age from 4 to 80 years (mean 22). Coma was secondary to head injury in ten patients, hypoxia in four, and brain tumour, with prolonged postoperative unconsciousness, in two. All diagnoses were supported by angiography and/or computerised tomographic scanning. Patients with traumatic, acute epi- dural, subdural, or intracerebral hxmorrhage were excluded from the series. The first neurological examinations were done within 6 h of onset of coma and repeated daily. I.A.H.P. environmental enrichment programmes were started 12-24 h after admission to hospital, except in the two postoperative brain-tumour pa- tients whose programmes started 10 and 14 days after surgery. Follow-up has ranged from several days to 10 months. There have been no deaths. All sixteen patients have fully re- covered -from coma. Of twelve patients who have regained functional independence and are home, eight have reaquired their premorbid condition and have no detectable deficit. The other four, although still displaying some focal physical deficit or adaptive behaviour disorder, are recovering progressively. One patient, more recently admitted, is still in hospital. Two others, though alert, are in other institutions because of severe physical handicaps and lack of family to care for them. Of a comparable group of fourteen consecutive patients, also in severe coma (all grade 3-5 on the Glasgow scale), admitted to hospital during the previous 12-month period and followed up by one of us (M.D.D.), but not given programmes of en- vironmental enrichment, eleven died (79%). The improved outcome in the I.A.H.P.-managed warrants continuation of this study. This letter condenses two papers-The Child in Coma (E.B.L.) and Coma recovery (M.D.D.)-presented to the llth annual meeting of the World Organisation for Human Potential, cosponsored by the National Aeronautics and Space Administration/Ames Research Center and the Institutes for the Achievement of Human Potential, at Moffett Field, California, on May 18,1978.

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EFFECT OF PHOTOTHERAPY ON SISTER CHROMATID EXCHANGE IN PREMATURE INFANTS

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