Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial

Hiten D. Patel; Farzana A. Faisal; Bruce J. Trock; Gregory A. Joice; Zeyad R. Schwen; Phillip M. Pierorazio; Michael H. Johnson; Trinity J. Bivalacqua; Misop Han; Michael A. Gorin; H. Ballentine Carter; Alan W. Partin; Christian P. Pavlovich; Mohamad E. Allaf

doi:10.1016/j.eururo.2020.05.001

Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial

Hiten D. Patel
, Farzana A. Faisal
, Bruce J. Trock
, Gregory A. Joice
, Zeyad R. Schwen
, Phillip M. Pierorazio
, Michael H. Johnson
, Trinity J. Bivalacqua
, Misop Han
, Michael A. Gorin
, H. Ballentine Carter
, Alan W. Partin
, Christian P. Pavlovich
, Mohamad E. Allaf

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

In the Prevention of Venous Thromboembolism Following Radical Prostatectomy (PREVENTER) randomized trial, pharmacologic prophylaxis did not reduce the rate of symptomatic (relative risk [RR] 0.40 [95% confidence interval {CI} 0.08–2.03], p = 0.267) or overall (RR 0.97 [95% CI 0.25–3.81], p = 0.967) venous thromboembolism significantly. There was no increase in adverse events including symptomatic lymphoceles or bleeding.

Original language	English
Pages (from-to)	360-368
Number of pages	9
Journal	European Urology
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/j.eururo.2020.05.001
State	Published - Sep 2020

Keywords

Clinical trial
Evidence-based medicine
Quality improvement
Radical prostatectomy
Surgery
Venous thromboembolism

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10.1016/j.eururo.2020.05.001

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Patel, H. D., Faisal, F. A., Trock, B. J., Joice, G. A., Schwen, Z. R., Pierorazio, P. M., Johnson, M. H., Bivalacqua, T. J., Han, M., Gorin, M. A., Carter, H. B., Partin, A. W., Pavlovich, C. P., & Allaf, M. E. (2020). Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial. European Urology, 78(3), 360-368. https://doi.org/10.1016/j.eururo.2020.05.001

@article{ff38b960cc9f416a9374aceff6c0f160,

title = "Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial",

abstract = "In the Prevention of Venous Thromboembolism Following Radical Prostatectomy (PREVENTER) randomized trial, pharmacologic prophylaxis did not reduce the rate of symptomatic (relative risk [RR] 0.40 [95\% confidence interval \{CI\} 0.08–2.03], p = 0.267) or overall (RR 0.97 [95\% CI 0.25–3.81], p = 0.967) venous thromboembolism significantly. There was no increase in adverse events including symptomatic lymphoceles or bleeding.",

keywords = "Clinical trial, Evidence-based medicine, Quality improvement, Radical prostatectomy, Surgery, Venous thromboembolism",

author = "Patel, \{Hiten D.\} and Faisal, \{Farzana A.\} and Trock, \{Bruce J.\} and Joice, \{Gregory A.\} and Schwen, \{Zeyad R.\} and Pierorazio, \{Phillip M.\} and Johnson, \{Michael H.\} and Bivalacqua, \{Trinity J.\} and Misop Han and Gorin, \{Michael A.\} and Carter, \{H. Ballentine\} and Partin, \{Alan W.\} and Pavlovich, \{Christian P.\} and Allaf, \{Mohamad E.\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = sep,

doi = "10.1016/j.eururo.2020.05.001",

language = "English",

volume = "78",

pages = "360--368",

journal = "European Urology",

issn = "0302-2838",

number = "3",

}

Patel, HD, Faisal, FA, Trock, BJ, Joice, GA, Schwen, ZR, Pierorazio, PM, Johnson, MH, Bivalacqua, TJ, Han, M, Gorin, MA, Carter, HB, Partin, AW, Pavlovich, CP & Allaf, ME 2020, 'Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial', European Urology, vol. 78, no. 3, pp. 360-368. https://doi.org/10.1016/j.eururo.2020.05.001

TY - JOUR

T1 - Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy

T2 - The PREVENTER Randomized Clinical Trial

AU - Patel, Hiten D.

AU - Faisal, Farzana A.

AU - Trock, Bruce J.

AU - Joice, Gregory A.

AU - Schwen, Zeyad R.

AU - Pierorazio, Phillip M.

AU - Johnson, Michael H.

AU - Bivalacqua, Trinity J.

AU - Han, Misop

AU - Gorin, Michael A.

AU - Carter, H. Ballentine

AU - Partin, Alan W.

AU - Pavlovich, Christian P.

AU - Allaf, Mohamad E.

PY - 2020/9

Y1 - 2020/9

N2 - In the Prevention of Venous Thromboembolism Following Radical Prostatectomy (PREVENTER) randomized trial, pharmacologic prophylaxis did not reduce the rate of symptomatic (relative risk [RR] 0.40 [95% confidence interval {CI} 0.08–2.03], p = 0.267) or overall (RR 0.97 [95% CI 0.25–3.81], p = 0.967) venous thromboembolism significantly. There was no increase in adverse events including symptomatic lymphoceles or bleeding.

AB - In the Prevention of Venous Thromboembolism Following Radical Prostatectomy (PREVENTER) randomized trial, pharmacologic prophylaxis did not reduce the rate of symptomatic (relative risk [RR] 0.40 [95% confidence interval {CI} 0.08–2.03], p = 0.267) or overall (RR 0.97 [95% CI 0.25–3.81], p = 0.967) venous thromboembolism significantly. There was no increase in adverse events including symptomatic lymphoceles or bleeding.

KW - Clinical trial

KW - Evidence-based medicine

KW - Quality improvement

KW - Radical prostatectomy

KW - Surgery

KW - Venous thromboembolism

UR - https://www.scopus.com/pages/publications/85084850948

U2 - 10.1016/j.eururo.2020.05.001

DO - 10.1016/j.eururo.2020.05.001

M3 - Article

C2 - 32444264

AN - SCOPUS:85084850948

SN - 0302-2838

VL - 78

SP - 360

EP - 368

JO - European Urology

JF - European Urology

IS - 3

ER -

Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial

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