Effect of obstructive sleep apnea on response to cognitive behavior therapy for depression after an acute myocardial infarction

Kenneth E. Freedland, Robert M. Carney, Junichiro Hayano, Brian C. Steinmeyer, Rebecca L. Reese, Annelieke M. Roest

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective: To determine whether obstructive sleep apnea (OSA) interferes with cognitive behavior therapy (CBT) for depression in patients with coronary heart disease. Methods: Patients who were depressed within 28. days after an acute myocardial infarction (MI) were enrolled in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) trial; 289 (12%) of the 2481 participants in ENRICHD met the criteria for inclusion in this ancillary study. Results: A validated ambulatory ECG algorithm was used to detect OSA. Of the 289 participants, 64 (22%) met the criteria for OSA. CBT was efficacious relative to usual care (UC) for depression (p=.004). OSA had no effect on 6-month Beck Depression Inventory (BDI) scores (p=.11), and there was no interaction between OSA and treatment (p=.42). However, the adjusted mean (s.e.) 6-month BDI scores among patients without OSA were 12.2 (0.8) vs. 9.0 (0.8) in the UC and CBT groups (Cohen's d=.40); among those with OSA, they were 9.5 (1.4) and 8.1 (1.5) in the UC and CBT groups (d=.17). There were no significant OSA × Treatment interactions in the major depression (n=131) or minor depression (n=158) subgroups, but in those with major depression, there was a larger treatment effect in those without (d=.44) than with (d=.09) OSA. In those with minor depression, the treatment effects were d=.37 and d=.25 for the non-OSA and OSA subgroups. Conclusion: CBT is efficacious for depression after an acute myocardial infarction in patients without obstructive sleep apnea, but it may be less efficacious for post-MI patients with OSA.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalJournal of Psychosomatic Research
Volume72
Issue number4
DOIs
StatePublished - Apr 1 2012

Keywords

  • Ambulatory
  • Cognitive Therapy
  • Depression
  • Depressive disorder/psychology
  • Depressive disorder/therapy
  • Electrocardiography
  • Myocardial infarction/psychology
  • Obstructive
  • Sleep apnea

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