Effect of multiple sclerosis disease-modifying therapies on b cells and humoral immunity

Erin E. Longbrake, Anne H. Cross

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The unequivocal success of B-cell-depleting agents in reducingmagnetic resonance imaging and clinical activity in therapeutic trials indicates that B cells play a vital role in mediating the clinical course of relapsing multiple sclerosis (MS). Although no agent that specifically targets B cells has yet been approved for clinical use, all existing disease-modifying therapies (DMTs) forMS modulate B-cell immunity to some degree. This review examines the effects of MS DMTs on B-cell immunity. MostMS DMTs induced a relative decrease in circulating memory B cells with concomitant expansion of circulating B-cell precursors and/or naive B cells. B-cell function was also altered; most DMTs induced B-cell production of the anti-inflammatory cytokine interleukin 10 while inhibiting B-cell expression of proinflammatory cytokines. The commonalities in the effects of approved DMTs on B-cell phenotype and function among treated patients with MS are striking and suggest that effects on B cells underlie part of their efficacy. More complete understanding of how the existing DMTs modulate B-cell immunity may identify future targets for therapeutic intervention.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalJAMA Neurology
Volume73
Issue number2
DOIs
StatePublished - Feb 2016

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