Effect of lithium on parathyroid hormone-induced calcium release from bone rudiments

Daniel T. Baran; James K. Burks; Catherine A. Richardson; Joan B. Hamilton; Linda R. Halstead; T. J. Hahn; Steven L. Teitelbaum; Louis V. Avioli

doi:10.1007/BF02441174

Effect of lithium on parathyroid hormone-induced calcium release from bone rudiments

Daniel T. Baran
, James K. Burks
, Catherine A. Richardson
, Joan B. Hamilton
, Linda R. Halstead
, T. J. Hahn
, Steven L. Teitelbaum
, Louis V. Avioli

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Lithium treatment of humans and animals has been associated with adverse effects on bone and mineral metabolism. In order to determine whether lithium was altering the skeletal response to parathyroid hormone, we incubated bone rudiments for 5 days in the presence or absence of the drugs. Lithium had no effect on either parathyroid hormone-induced cyclic AMP generation or⁴⁵Ca release from the bone rudiments. The data are consistent with the hypothesis that the skeletal effects of lithium are not mediated via inhibition of the parathyroid hormone-adenyl cyclase-cyclic AMP system.

Original language	English
Pages (from-to)	127-128
Number of pages	2
Journal	Calcified Tissue International
Volume	27
Issue number	1
DOIs	https://doi.org/10.1007/BF02441174
State	Published - Dec 1979

Keywords

Bone rudiments
Lithium
Parathyroid hormone

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10.1007/BF02441174

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@article{a6839a5518164e1598d4dcb86411c342,

title = "Effect of lithium on parathyroid hormone-induced calcium release from bone rudiments",

abstract = "Lithium treatment of humans and animals has been associated with adverse effects on bone and mineral metabolism. In order to determine whether lithium was altering the skeletal response to parathyroid hormone, we incubated bone rudiments for 5 days in the presence or absence of the drugs. Lithium had no effect on either parathyroid hormone-induced cyclic AMP generation or45Ca release from the bone rudiments. The data are consistent with the hypothesis that the skeletal effects of lithium are not mediated via inhibition of the parathyroid hormone-adenyl cyclase-cyclic AMP system.",

keywords = "Bone rudiments, Lithium, Parathyroid hormone",

author = "Baran, \{Daniel T.\} and Burks, \{James K.\} and Richardson, \{Catherine A.\} and Hamilton, \{Joan B.\} and Halstead, \{Linda R.\} and Hahn, \{T. J.\} and Teitelbaum, \{Steven L.\} and Avioli, \{Louis V.\}",

year = "1979",

month = dec,

doi = "10.1007/BF02441174",

language = "English",

volume = "27",

pages = "127--128",

journal = "Calcified Tissue International",

issn = "0171-967X",

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TY - JOUR

T1 - Effect of lithium on parathyroid hormone-induced calcium release from bone rudiments

AU - Baran, Daniel T.

AU - Burks, James K.

AU - Richardson, Catherine A.

AU - Hamilton, Joan B.

AU - Halstead, Linda R.

AU - Hahn, T. J.

AU - Teitelbaum, Steven L.

AU - Avioli, Louis V.

PY - 1979/12

Y1 - 1979/12

N2 - Lithium treatment of humans and animals has been associated with adverse effects on bone and mineral metabolism. In order to determine whether lithium was altering the skeletal response to parathyroid hormone, we incubated bone rudiments for 5 days in the presence or absence of the drugs. Lithium had no effect on either parathyroid hormone-induced cyclic AMP generation or45Ca release from the bone rudiments. The data are consistent with the hypothesis that the skeletal effects of lithium are not mediated via inhibition of the parathyroid hormone-adenyl cyclase-cyclic AMP system.

AB - Lithium treatment of humans and animals has been associated with adverse effects on bone and mineral metabolism. In order to determine whether lithium was altering the skeletal response to parathyroid hormone, we incubated bone rudiments for 5 days in the presence or absence of the drugs. Lithium had no effect on either parathyroid hormone-induced cyclic AMP generation or45Ca release from the bone rudiments. The data are consistent with the hypothesis that the skeletal effects of lithium are not mediated via inhibition of the parathyroid hormone-adenyl cyclase-cyclic AMP system.

KW - Bone rudiments

KW - Lithium

KW - Parathyroid hormone

UR - https://www.scopus.com/pages/publications/0018717137

U2 - 10.1007/BF02441174

DO - 10.1007/BF02441174

M3 - Article

C2 - 222405

AN - SCOPUS:0018717137

SN - 0171-967X

VL - 27

SP - 127

EP - 128

JO - Calcified Tissue International

JF - Calcified Tissue International

IS - 1

ER -

Effect of lithium on parathyroid hormone-induced calcium release from bone rudiments

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Keywords

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