@inproceedings{dc3a164fe1c3472ba2b347b13bc5d8dd,
title = "Effect of light scattering on optical-resolution photoacoustic microscopy",
abstract = "The penetration depth of ballistic optical imaging technologies is limited by light scattering. To study the effect of scattering on optical-resolution photoacoustic microscopy (OR-PAM), we divided the signals in OR-PAM into two classes: one is from the target volume defined by the optical resolution cell (Class I); the other is from the rest of the acoustic resolution cell (Class II). We developed a way to simulate the point spread function (PSF) of our OR-PAM system considering both optical illumination and acoustic detection, then used the PSF to calculate the contributions of each class of signal to the total signal at different focal depths. Our simulation results showed that: 1) The Class II signal decays much more slowly than the Class I signal; 2) The full width at half maximum (FWHM) of the PSF for the focal depth of 0.9 transport mean free path (TMFP) is not broadened much (∼10\%) compared with that for a clear medium; 3) Image contrast is degraded with increasing depth when there is a uniform absorption background.",
keywords = "Light scattering, Optical-resolution photoacoustic microscopy, Penetration depth",
author = "Yan Liu and Chi Zhang and Song Hu and Yuta Suzuki and Zhun Xu and Silvina Ferradal and Wang, \{Lihong V.\}",
year = "2012",
month = feb,
day = "9",
doi = "10.1117/12.909373",
language = "English",
isbn = "9780819488664",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2012 ; Conference date: 22-01-2012 Through 24-01-2012",
}