Effect of L-DOPA pretreatment on in vivo protein synthesis in various rat brain regions

L. E. Roel; P. Levine; D. Rubin; D. Markovitz; H. N. Munro; R. J. Wurtman

doi:10.1016/0024-3205(78)90475-7

Effect of L-DOPA pretreatment on in vivo protein synthesis in various rat brain regions

L. E. Roel
, P. Levine
, D. Rubin
, D. Markovitz
, H. N. Munro
, R. J. Wurtman

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [³H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [³H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid.

Original language	English
Pages (from-to)	1887-1891
Number of pages	5
Journal	Life Sciences
Volume	22
Issue number	21
DOIs	https://doi.org/10.1016/0024-3205(78)90475-7
State	Published - Jun 5 1978

Access to Document

10.1016/0024-3205(78)90475-7

Cite this

@article{a60a05e3898a40afae8a1f2664055388,

title = "Effect of L-DOPA pretreatment on in vivo protein synthesis in various rat brain regions",

abstract = "A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [3H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [3H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid.",

author = "Roel, \{L. E.\} and P. Levine and D. Rubin and D. Markovitz and Munro, \{H. N.\} and Wurtman, \{R. J.\}",

year = "1978",

month = jun,

day = "5",

doi = "10.1016/0024-3205(78)90475-7",

language = "English",

volume = "22",

pages = "1887--1891",

journal = "Life Sciences",

issn = "0024-3205",

number = "21",

}

TY - JOUR

T1 - Effect of L-DOPA pretreatment on in vivo protein synthesis in various rat brain regions

AU - Roel, L. E.

AU - Levine, P.

AU - Rubin, D.

AU - Markovitz, D.

AU - Munro, H. N.

AU - Wurtman, R. J.

PY - 1978/6/5

Y1 - 1978/6/5

N2 - A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [3H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [3H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid.

AB - A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [3H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [3H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid.

UR - https://www.scopus.com/pages/publications/0018098704

U2 - 10.1016/0024-3205(78)90475-7

DO - 10.1016/0024-3205(78)90475-7

M3 - Article

C2 - 672434

AN - SCOPUS:0018098704

SN - 0024-3205

VL - 22

SP - 1887

EP - 1891

JO - Life Sciences

JF - Life Sciences

IS - 21

ER -

Effect of L-DOPA pretreatment on in vivo protein synthesis in various rat brain regions

Abstract

Access to Document

Other files and links

Fingerprint

Cite this