Effect of L-DOPA pretreatment on in vivo protein synthesis in various rat brain regions

L. E. Roel; P. Levine; D. Rubin; D. Markovitz; H. N. Munro; R. J. Wurtman

doi:10.1016/0024-3205(78)90475-7

Effect of L-DOPA pretreatment on in vivo protein synthesis in various rat brain regions

L. E. Roel, P. Levine, D. Rubin, D. Markovitz, H. N. Munro, R. J. Wurtman

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Abstract

A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [³H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [³H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid.

Original language	English
Pages (from-to)	1887-1891
Number of pages	5
Journal	Life Sciences
Volume	22
Issue number	21
DOIs	https://doi.org/10.1016/0024-3205(78)90475-7
State	Published - Jun 5 1978

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abstract = "A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [3H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [3H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid.",

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AU - Roel, L. E.

AU - Levine, P.

AU - Rubin, D.

AU - Markovitz, D.

AU - Munro, H. N.

AU - Wurtman, R. J.

PY - 1978/6/5

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N2 - A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [3H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [3H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid.

AB - A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [3H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [3H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid.

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VL - 22

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EP - 1891

JO - Life Sciences

JF - Life Sciences

IS - 21

ER -

Effect of L-DOPA pretreatment on in vivo protein synthesis in various rat brain regions

Abstract

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