TY - JOUR
T1 - Effect of imidazole on renal gluconeogenesis
AU - Schoolwerth, Anton C.
AU - Morrison, Aubrey R.
AU - Yates, Yesse
AU - Klahr, Saulo
N1 - Funding Information:
This research was supported by U.S.P.H.S. Grants AM-09976 and AM~)5248. This work was presented in part at the annual meeting of the American Federation for Clinical Research, Atlantic City, N.J. May 3--5, 1975, and an abstract has been published, Clin. Res. XXIII, 373a, 1975. The assistance of Mrs. Kathy Rill in the preparation of the manuscript is kindly appreciated.
PY - 1976/10/22
Y1 - 1976/10/22
N2 - The metabolic effects of imidazole were tested in rat renal cortex. Imidazole enhanced the activity of renal cortical phosphodiesterase in vitro. Imidazole inhibited glucose production in a dose-dependent fashion from a variety of substrates in the gluconeogenic pathway proximal to the triose phosphates. The stimulation in renal gluconeogenesis resulting from isoproterenol and parathyroid hormone was inhibited by imidazole. These changes correlated with an inhibition of the augmented levels of renal cortical cyclic AMP levels produced by these hormones. These studies indicate that imidazole is an effective activator of phosphodiesterase in intact renal cells and lend further support to the suggestion that the stimulation of renal gluconeogenesis produced by isoproterenol and parathyroid hormone is mediated by a release of cyclic AMP.
AB - The metabolic effects of imidazole were tested in rat renal cortex. Imidazole enhanced the activity of renal cortical phosphodiesterase in vitro. Imidazole inhibited glucose production in a dose-dependent fashion from a variety of substrates in the gluconeogenic pathway proximal to the triose phosphates. The stimulation in renal gluconeogenesis resulting from isoproterenol and parathyroid hormone was inhibited by imidazole. These changes correlated with an inhibition of the augmented levels of renal cortical cyclic AMP levels produced by these hormones. These studies indicate that imidazole is an effective activator of phosphodiesterase in intact renal cells and lend further support to the suggestion that the stimulation of renal gluconeogenesis produced by isoproterenol and parathyroid hormone is mediated by a release of cyclic AMP.
UR - http://www.scopus.com/inward/record.url?scp=0017176311&partnerID=8YFLogxK
U2 - 10.1016/0304-4165(76)90314-7
DO - 10.1016/0304-4165(76)90314-7
M3 - Article
C2 - 10972
AN - SCOPUS:0017176311
SN - 0304-4165
VL - 444
SP - 674
EP - 684
JO - BBA - General Subjects
JF - BBA - General Subjects
IS - 3
ER -