Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states

Jane L. Liesveld, Camille N. Abboud, Frank T. Slovick, Jacob M. Rowe, James K. Brennan

Research output: Contribution to journalArticle

Abstract

The growth of eosinophil progenitors (CFU‐Eo) and its modulation by hydrocortisone (HC), mononuclear cells, interleukin 1 (IL‐1), and interleukin 2 (IL‐2) in three cases of eosinophilia are reported in this paper. One m̈M HC decreased the proportion of CFU‐Eo in each of these three patients, and in each case, the addition of autologous mononuclear cells at a 1:1 ratio abrogated the effect of HC on CFU‐Eo. As studied in two of the three cases, IL‐1 and IL‐2 were able to prevent the effect of HC. Further studies showed no effect of HC when monocyte T cell‐depleted marrow cells were used as the target population. These results suggest that CFU‐Eo production in eosinophilic states is subject to modulation by HC and T lymphocytes.

Original languageEnglish
Pages (from-to)404-416
Number of pages13
JournalThe International Journal of Cell Cloning
Volume6
Issue number6
DOIs
StatePublished - 1988
Externally publishedYes

Keywords

  • CFU‐Eo
  • Hydrocortisone
  • Hypereosinophilia
  • Interleukins

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