Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states

Jane L. Liesveld; Camille N. Abboud; Frank T. Slovick; Jacob M. Rowe; James K. Brennan

doi:10.1002/stem.5530060605

Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states

Jane L. Liesveld, Camille N. Abboud, Frank T. Slovick, Jacob M. Rowe, James K. Brennan

Research output: Contribution to journal › Article › peer-review

Abstract

The growth of eosinophil progenitors (CFU‐Eo) and its modulation by hydrocortisone (HC), mononuclear cells, interleukin 1 (IL‐1), and interleukin 2 (IL‐2) in three cases of eosinophilia are reported in this paper. One m̈M HC decreased the proportion of CFU‐Eo in each of these three patients, and in each case, the addition of autologous mononuclear cells at a 1:1 ratio abrogated the effect of HC on CFU‐Eo. As studied in two of the three cases, IL‐1 and IL‐2 were able to prevent the effect of HC. Further studies showed no effect of HC when monocyte T cell‐depleted marrow cells were used as the target population. These results suggest that CFU‐Eo production in eosinophilic states is subject to modulation by HC and T lymphocytes.

Original language	English
Pages (from-to)	404-416
Number of pages	13
Journal	The International Journal of Cell Cloning
Volume	6
Issue number	6
DOIs	https://doi.org/10.1002/stem.5530060605
State	Published - 1988

Keywords

CFU‐Eo
Hydrocortisone
Hypereosinophilia
Interleukins

Access to Document

10.1002/stem.5530060605

Cite this

@article{04d6f93555d84b889215541146133c6d,

title = "Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states",

abstract = "The growth of eosinophil progenitors (CFU‐Eo) and its modulation by hydrocortisone (HC), mononuclear cells, interleukin 1 (IL‐1), and interleukin 2 (IL‐2) in three cases of eosinophilia are reported in this paper. One {\"m}M HC decreased the proportion of CFU‐Eo in each of these three patients, and in each case, the addition of autologous mononuclear cells at a 1:1 ratio abrogated the effect of HC on CFU‐Eo. As studied in two of the three cases, IL‐1 and IL‐2 were able to prevent the effect of HC. Further studies showed no effect of HC when monocyte T cell‐depleted marrow cells were used as the target population. These results suggest that CFU‐Eo production in eosinophilic states is subject to modulation by HC and T lymphocytes.",

keywords = "CFU‐Eo, Hydrocortisone, Hypereosinophilia, Interleukins",

author = "Liesveld, {Jane L.} and Abboud, {Camille N.} and Slovick, {Frank T.} and Rowe, {Jacob M.} and Brennan, {James K.}",

year = "1988",

doi = "10.1002/stem.5530060605",

language = "English",

volume = "6",

pages = "404--416",

journal = "The International Journal of Cell Cloning",

issn = "0737-1454",

number = "6",

}

TY - JOUR

T1 - Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states

AU - Liesveld, Jane L.

AU - Abboud, Camille N.

AU - Slovick, Frank T.

AU - Rowe, Jacob M.

AU - Brennan, James K.

PY - 1988

Y1 - 1988

N2 - The growth of eosinophil progenitors (CFU‐Eo) and its modulation by hydrocortisone (HC), mononuclear cells, interleukin 1 (IL‐1), and interleukin 2 (IL‐2) in three cases of eosinophilia are reported in this paper. One m̈M HC decreased the proportion of CFU‐Eo in each of these three patients, and in each case, the addition of autologous mononuclear cells at a 1:1 ratio abrogated the effect of HC on CFU‐Eo. As studied in two of the three cases, IL‐1 and IL‐2 were able to prevent the effect of HC. Further studies showed no effect of HC when monocyte T cell‐depleted marrow cells were used as the target population. These results suggest that CFU‐Eo production in eosinophilic states is subject to modulation by HC and T lymphocytes.

AB - The growth of eosinophil progenitors (CFU‐Eo) and its modulation by hydrocortisone (HC), mononuclear cells, interleukin 1 (IL‐1), and interleukin 2 (IL‐2) in three cases of eosinophilia are reported in this paper. One m̈M HC decreased the proportion of CFU‐Eo in each of these three patients, and in each case, the addition of autologous mononuclear cells at a 1:1 ratio abrogated the effect of HC on CFU‐Eo. As studied in two of the three cases, IL‐1 and IL‐2 were able to prevent the effect of HC. Further studies showed no effect of HC when monocyte T cell‐depleted marrow cells were used as the target population. These results suggest that CFU‐Eo production in eosinophilic states is subject to modulation by HC and T lymphocytes.

KW - CFU‐Eo

KW - Hydrocortisone

KW - Hypereosinophilia

KW - Interleukins

UR - http://www.scopus.com/inward/record.url?scp=0023760746&partnerID=8YFLogxK

U2 - 10.1002/stem.5530060605

DO - 10.1002/stem.5530060605

M3 - Article

C2 - 3265948

AN - SCOPUS:0023760746

SN - 0737-1454

VL - 6

SP - 404

EP - 416

JO - The International Journal of Cell Cloning

JF - The International Journal of Cell Cloning

IS - 6

ER -

Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this