Effect of ganglionic blockade on bronchial reactivity in atopic subjects

M. J. Holtzman, J. R. Sheller, M. Dimeo, J. A. Nadel, H. A. Boushey

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Abstract

To determine the site in the parasympathetic pathway responsible for the increased bronchial reactivity in 5 atopic subjects, the authors studied the effect of premedication with aerosols of hexamethonium, a ganglionic blocking agent, and atropine, a postganglionic blocking agent, on the bronchomotor responses to histamine and methacholine aerosols. After 7 mg of aerosolized atropine, baseline specific airway resistance (SRaw) decreased, and the increases in SRaw produced by histamine and by methacholine were prevented in each subject (p < 0.001). After 1 g of hexamethonium, baseline SRaw was decreased to a similar level, and the increase in SRaw produced by histamine was again prevented in each subject (p < 0.001); however, the increase in SRaw produced by methacholine was not affected significantly in 3 subjects (p > 0.5) and was increased or decreased only slightly in 2 subjects (p < 0.05). These results suggest that bronchial hyperreactivity in atopic subjects may be due to a change in the characteristics of the efferent parasympathetic pathway at a site distal to the ganglion, possibly at the smooth muscle, and that bronchodilation caused by atropine and hexamethonium cannot, by itself, account for their effects on bronchomotor responses.

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalAmerican Review of Respiratory Disease
Volume122
Issue number1
StatePublished - Aug 29 1980

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