TY - JOUR
T1 - Effect of fusaric acid on aggression, motor activity, and brain monoamines in mice
AU - Diringer, Michael N.
AU - Kramarcy, Neal R.
AU - Brown, John W.
AU - Thurmond, John B.
PY - 1982/1
Y1 - 1982/1
N2 - The effects of fusaric acid (FA), a dopamine-β-hydroxylase (DβH) inhibitor, were determined on aggression, motor activity, and brain monoamines at doses of 3.2 to 60 mg/kg following administration of dietary supplements of L-tyrosine or balanced protein to male albino mice. Compared to saline injected control animals, both aggression and motor activity were reduced by the highest doses of FA. Somewhat more reduction in aggression was observed in animals administered dietary supplements of casein compared to those given the tyrosine supplement. Treatment with FA at doses of 30 to 60 mg/kg decreased brain norepinephrine and dopamine, and decreased brain tyrosine in animals fed the tyrosine supplement. In contrast, FA increased 5-hydroxytryptamine, and caused marked increases in 5-hydroxyindoleacetic acid at the highest doses. The data suggest that the neurochemical effects of FA may not be the same in rats and mice.
AB - The effects of fusaric acid (FA), a dopamine-β-hydroxylase (DβH) inhibitor, were determined on aggression, motor activity, and brain monoamines at doses of 3.2 to 60 mg/kg following administration of dietary supplements of L-tyrosine or balanced protein to male albino mice. Compared to saline injected control animals, both aggression and motor activity were reduced by the highest doses of FA. Somewhat more reduction in aggression was observed in animals administered dietary supplements of casein compared to those given the tyrosine supplement. Treatment with FA at doses of 30 to 60 mg/kg decreased brain norepinephrine and dopamine, and decreased brain tyrosine in animals fed the tyrosine supplement. In contrast, FA increased 5-hydroxytryptamine, and caused marked increases in 5-hydroxyindoleacetic acid at the highest doses. The data suggest that the neurochemical effects of FA may not be the same in rats and mice.
KW - Aggressive behavior
KW - Dietary tyrosine
KW - Dopamine
KW - Dopamine-β-hydroxylase
KW - Fusaric acid
KW - Motor activity
KW - Norepinephrine
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=0020026006&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(82)90016-8
DO - 10.1016/0091-3057(82)90016-8
M3 - Article
C2 - 6173886
AN - SCOPUS:0020026006
SN - 0091-3057
VL - 16
SP - 73
EP - 79
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 1
ER -